BC000465
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,121 Da
NCBI Official Full Name
Homo sapiens growth arrest and DNA-damage-inducible, gamma, mRNA
NCBI Official Synonym Full Names
growth arrest and DNA damage inducible gamma
NCBI Protein Information
growth arrest and DNA damage-inducible protein GADD45 gamma
UniProt Protein Name
Growth arrest and DNA damage-inducible protein GADD45 gamma
UniProt Synonym Protein Names
Cytokine-responsive protein CR6; DNA damage-inducible transcript 2 protein; DDIT-2
UniProt Synonym Gene Names
UniProt Entry Name
GA45G_HUMAN
NCBI Summary for GADD45G
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
UniProt Comments for GADD45G
GADD45G: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. Belongs to the GADD45 family.
Protein type: DNA repair, damage; Apoptosis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 9q22.1-q22.2
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding
Biological Process: activation of MAPKKK activity; positive regulation of apoptosis; positive regulation of JNK cascade
Research Articles on GADD45G
Precautions
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Pathways associated with GADD45G cdna clone
Diseases associated with GADD45G cdna clone
Organs/Tissues associated with GADD45G cdna clone
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