BC130524
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,531 Da
NCBI Official Full Name
Homo sapiens glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group), mRNA
NCBI Official Synonym Full Names
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
NCBI Official Synonym Symbols
II; CCAT; IGNT; ULG3; GCNT5; GCNT2C; NACGT1; NAGCT1; CTRCT13; bA421M1.1; bA360O19.2 [Similar Products]
NCBI Protein Information
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
UniProt Protein Name
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
UniProt Synonym Protein Names
I-branching enzyme; IGNT
UniProt Synonym Gene Names
UniProt Entry Name
GNT2A_HUMAN
NCBI Summary for GCNT2
This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for GCNT2
GCNT2: Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C. Belongs to the glycosyltransferase 14 family. 3 isoforms of the human protein are produced by alternative splicing
Protein type: EC 2.4.1.150; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6p24.2
Cellular Component: membrane
Molecular Function: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
Biological Process: glycosaminoglycan biosynthetic process; multicellular organismal development; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of heterotypic cell-cell adhesion; positive regulation of protein kinase B signaling cascade; protein amino acid glycosylation; transforming growth factor beta receptor signaling pathway
Disease: Blood Group, I System
Research Articles on GCNT2
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Pathways associated with GCNT2 cdna clone
Diseases associated with GCNT2 cdna clone
Organs/Tissues associated with GCNT2 cdna clone
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