BC113546
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,727 Da
NCBI Official Full Name
Homo sapiens gonadotropin-releasing hormone receptor, mRNA
NCBI Official Synonym Full Names
gonadotropin releasing hormone receptor
NCBI Protein Information
gonadotropin-releasing hormone receptor
UniProt Protein Name
Gonadotropin-releasing hormone receptor
UniProt Synonym Gene Names
UniProt Entry Name
GNRHR_HUMAN
NCBI Summary for GNRHR
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for GNRHR
GNRHR: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. Defects in GNRHR are a cause of idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. Defects in GNRHR are a cause of fertile eunuch syndrome (FEUNS). Fertile eunuch syndrome is a mild phenotypic form of HH going with the presence of normal testicular size and some degree of spermatogenesis. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1
Chromosomal Location of Human Ortholog: 4q21.2
Cellular Component: integral to plasma membrane; membrane; plasma membrane
Molecular Function: peptide binding
Biological Process: multicellular organismal development
Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
Research Articles on GNRHR
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Pathways associated with GNRHR cdna clone
Diseases associated with GNRHR cdna clone
Organs/Tissues associated with GNRHR cdna clone
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