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GPX3 cdna clone

Scan QR to view Datasheet Catalog #    MBS1271166 GPX3 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GPX3, cDNA Clone

★Popular Item★
 Also Known As   

GPX3 cDNA Clone

 Product Gene Name   

GPX3 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggcccggc tgctgcaggc gtcctgcctg ctttccctgc tcctggccgg cttcgtctcg cagagccggg gacaagagaa gtcgaagatg gactgccatg gtggcataag tggcaccatt tacgagtacg gagccctcac cattgatggg gaggagtaca tccccttcaa gcagtatgct ggcaaatacg tcctctttgt caacgtggcc agctactgag gcctgacggg ccagtacatt gaactgaatg cactacagga agagcttgca ccattcggtc tggtcattct gggctttccc tgcaaccaat ttggaaaaca ggaaccagga gagaactcag agatccttcc taccctcaag tatgtccgac caggtggagg ctttgtccct aatttccagc tctttgagaa aggggatgtc aatggagaga aagagcagaa attctacact ttcctaaaga actcctgtcc tcccacctcg gagctcctgg gtacatctga ccgcctcttc tgggaaccca tgaaggttca cgacatccgc tggaactttg agaagttcct ggtggggcca gatggtatac ccatcatgcg ctggcaccac cggaccacgg tcagcaacgt caagatggac atcctgtcct acatgaggcg gcaggcagcc ctgggggtca agaggaagta a
 OMIM    138321
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of GPX3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for GPX3. It may not necessarily be applicable to this product.
 NCBI GI #    15488949
 NCBI GeneID    2878
 NCBI Accession #    BC013601 [Other Products]
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 UniProt Secondary Accession #    O43787; Q86W78; Q9NZ74; Q9UEL1 [Other Products]
 UniProt Related Accession #    P22352 [Other Products]
 Molecular Weight    25,552 Da
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 NCBI Official Full Name    Homo sapiens glutathione peroxidase 3 (plasma), mRNA
 NCBI Official Synonym Full Names    glutathione peroxidase 3
 NCBI Official Symbol    GPX3 [Similar Products]
 NCBI Official Synonym Symbols   
GPx-P; GSHPx-3; GSHPx-P
[Similar Products]
 NCBI Protein Information    glutathione peroxidase 3
 UniProt Protein Name    Glutathione peroxidase 3
 UniProt Synonym Protein Names   
Extracellular glutathione peroxidase; Plasma glutathione peroxidase; GPx-P; GSHPx-P
 Protein Family    Probable glutathione peroxidase
 UniProt Gene Name    GPX3 [Similar Products]
 UniProt Synonym Gene Names    GPXP; GPx-3; GSHPx-3; GPx-P; GSHPx-P [Similar Products]
 UniProt Entry Name    GPX3_HUMAN
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 NCBI Summary for GPX3    The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
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 UniProt Comments for GPX3    GPX3: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. Belongs to the glutathione peroxidase family.

Protein type: Oxidoreductase; Secreted; Secreted, signal peptide; EC 1.11.1.9; Other Amino Acids Metabolism - glutathione; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: extracellular region; extracellular space

Molecular Function: glutathione peroxidase activity; protein binding; selenium binding; transcription factor binding

Biological Process: hydrogen peroxide catabolic process; protein homotetramerization; response to lipid hydroperoxide; response to reactive oxygen species
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 Research Articles on GPX3    1. A three-way interaction among maternal and fetal variants in BHMT2, GSTP1 and GPX3 contribute to congenital heart defects
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with GPX3 cdna cloneDiseases associated with GPX3 cdna clone
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Oxidative Stress Pathway antibodies  Oxidative Stress Pathway Diagram
 Selenium Metabolism And Selenoproteins Pathway antibodies  Selenium Metabolism And Selenoproteins Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
 Glutathione Redox Reactions I Pathway antibodies  Glutathione Redox Reactions I Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >38 publications with GPX3 and Neoplasms
 Cardiovascular Diseases Antibodies  >22 publications with GPX3 and Cardiovascular Diseases
 Inflammation Antibodies  >19 publications with GPX3 and Inflammation
 Nervous System Diseases Antibodies  >13 publications with GPX3 and Nervous System Diseases
 Adenocarcinoma Antibodies  >12 publications with GPX3 and Adenocarcinoma
 Necrosis Antibodies  >11 publications with GPX3 and Necrosis
 Brain Diseases Antibodies  >10 publications with GPX3 and Brain Diseases
 Obesity Antibodies  >8 publications with GPX3 and Obesity
 Prostatic Neoplasms Antibodies  >8 publications with GPX3 and Prostatic Neoplasms
 Drug Toxicity Antibodies  >8 publications with GPX3 and Drug Toxicity
Organs/Tissues associated with GPX3 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >79 publications with GPX3 and Blood
 Liver Antibodies  >32 publications with GPX3 and Liver
 Kidney Antibodies  >27 publications with GPX3 and Kidney
 Muscle Antibodies  >21 publications with GPX3 and Muscle
 Lung Antibodies  >17 publications with GPX3 and Lung
 Thyroid Antibodies  >17 publications with GPX3 and Thyroid
 Heart Antibodies  >14 publications with GPX3 and Heart
 Prostate Antibodies  >11 publications with GPX3 and Prostate
 Brain Antibodies  >10 publications with GPX3 and Brain
 Adipose Tissue Antibodies  >10 publications with GPX3 and Adipose Tissue
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