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GRIK2 cdna clone

Scan QR to view Datasheet Catalog #    MBS1275934 GRIK2 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GRIK2, cDNA Clone

 Also Known As   

GRIK2 cDNA Clone

 Product Gene Name   

GRIK2 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgaagatta ttttcccgat tctaagtaat ccagtcttca ggcgcaccgt taaactcctg ctctgtttac tgtggattgg atattctcaa ggaaccacac atgtattaag atttggtggt atttttgaat atgtggaatc tggcccaatg ggagctgagg aacttgcatt cagatttgct gtgaacacaa ttaacagaaa cagaacattg ctacccaata ctacccttac ctatgatacc cagaagataa acctttatga tagttttgaa gcatccaaga aagcctgtga tcagctgtct cttggggtgg ctgccatctt cgggccttca cacagctcat cagcaaacgc agtgcagtcc atctgcaatg ctctgggagt tccccacata cagacccgct ggaagcacca ggtgtcagac aacaaagatt ccttctatgt cagtctctac ccagacttct cttcactcag ccgtgccatt ttagacctgg tgcagttttt caagtggaaa accgtcacgg ttgtgtatga tgacagcact ggtctcattc gtttgcaaga gctcatcaaa gctccatcaa ggtataatct tcgactcaaa attcgtcagt tacctgctga tacaaaggat gcaaaaccct tactaaaaga aatgaaaaga ggcaaggagt ttcatgtaat ctttgattgt agccatgaaa tggcagcagg cattttaaaa caggcattag ctatgggaat gatgacagaa tactatcatt atatctttac cactctggac ctctttgctc ttgatgttga gccctaccga tacagtggtg ttaacatgac agggttcaga atattaaata cagaaaatac ccaagtctcc tccatcattg aaaagtggtc gatggaacga ttgcaggcac ctccgaaacc cgattcaggt ttgctggatg gatttatgac gatggagttt cactcttgtt gcccaggctg gagtgcaatg gcgcgatctc acctcactgc aacctctgcc tcctgggttc aagcgattct tctgcctcag cctcccgagt ag
 OMIM    138244
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of GRIK2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for GRIK2. It may not necessarily be applicable to this product.
 NCBI GI #    23274207
 NCBI GeneID    2898
 NCBI Accession #    BC037954 [Other Products]
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 UniProt Secondary Accession #    Q8WWS1; Q96KS6; Q96KS7; Q96KS8; A6NMY9; B5MCV0; D7RWZ3; D7RWZ4; D7RWZ5; D7RWZ6; D7RWZ7 [Other Products]
 UniProt Related Accession #    Q13002 [Other Products]
 Molecular Weight    77,112 Da
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 NCBI Official Full Name    Homo sapiens glutamate receptor, ionotropic, kainate 2, mRNA
 NCBI Official Synonym Full Names    glutamate ionotropic receptor kainate type subunit 2
 NCBI Official Symbol    GRIK2 [Similar Products]
 NCBI Official Synonym Symbols   
EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2
[Similar Products]
 NCBI Protein Information    glutamate receptor ionotropic, kainate 2
 UniProt Protein Name    Glutamate receptor ionotropic, kainate 2
 UniProt Synonym Protein Names   
Excitatory amino acid receptor 4; EAA4; Glutamate receptor 6; GluR-6; GluR6
 Protein Family    Glutamate receptor ionotropic
 UniProt Gene Name    GRIK2 [Similar Products]
 UniProt Synonym Gene Names    GLUR6; GluK2; EAA4; GluR-6; GluR6 [Similar Products]
 UniProt Entry Name    GRIK2_HUMAN
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 NCBI Summary for GRIK2    Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GRIK2    GluR6: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2. Defects in GRIK2 are the cause of mental retardation autosomal recessive type 6 (MRT6). It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 6q16.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: kainate selective glutamate receptor activity; ligand-gated ion channel activity

Biological Process: glutamate signaling pathway; positive regulation of synaptic transmission; regulation of short-term neuronal synaptic plasticity; regulation of synaptic transmission; synaptic transmission

Disease: Mental Retardation, Autosomal Recessive 6
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 Research Articles on GRIK2    1. This study found in GRIK2 (glutamate receptor, ionotropic kainate 2) was most significant and also showed significant correlations with gene expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with GRIK2 cdna cloneDiseases associated with GRIK2 cdna clone
 Products by Pathway  Pathway Diagram
 Activation Of Ca-permeable Kainate Receptor Pathway antibodies  Activation Of Ca-permeable Kainate Receptor Pathway Diagram
 Activation Of Kainate Receptors Upon Glutamate Binding Pathway antibodies  Activation Of Kainate Receptors Upon Glutamate Binding Pathway Diagram
 Activation Of Na-permeable Kainate Receptors Pathway antibodies  Activation Of Na-permeable Kainate Receptors Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Ionotropic Activity Of Kainate Receptors Pathway antibodies  Ionotropic Activity Of Kainate Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >30 publications with GRIK2 and Mental Disorders
 Nervous System Diseases Antibodies  >15 publications with GRIK2 and Nervous System Diseases
 Schizophrenia Antibodies  >7 publications with GRIK2 and Schizophrenia
 Mood Disorders Antibodies  >7 publications with GRIK2 and Mood Disorders
 Neurobehavioral Manifestations Antibodies  >6 publications with GRIK2 and Neurobehavioral Manifestations
 Autistic Disorder Antibodies  >6 publications with GRIK2 and Autistic Disorder
 Brain Diseases Antibodies  >6 publications with GRIK2 and Brain Diseases
 Movement Disorders Antibodies  >5 publications with GRIK2 and Movement Disorders
 Depressive Disorder Antibodies  >5 publications with GRIK2 and Depressive Disorder
 Cognition Disorders Antibodies  >4 publications with GRIK2 and Cognition Disorders
Organs/Tissues associated with GRIK2 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >20 publications with GRIK2 and Brain
 Nerve Antibodies  >6 publications with GRIK2 and Nerve
 Lung Antibodies  >2 publications with GRIK2 and Lung
 Eye Antibodies  >2 publications with GRIK2 and Eye
 Embryonic Tissue Antibodies  >2 publications with GRIK2 and Embryonic Tissue
 Kidney Antibodies  >2 publications with GRIK2 and Kidney
 Bone Antibodies  >1 publications with GRIK2 and Bone
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