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GRIN2B cdna clone

Scan QR to view Datasheet Catalog #    MBS1267817 GRIN2B cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $1,780 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GRIN2B, cDNA Clone

 Also Known As   

GRIN2B cDNA Clone

 Product Gene Name   

GRIN2B cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgaagccca gagcggagtg ctgttctccc aagttctggt tggtgttggc cgtcctggcc gtgtcaggca gcagagctcg ttctcagaag agccccccca gcattggcat tgctgtcatc ctcgtgggca cttccgacga ggtggccatc aaggatgccc acgagaaaga tgatttccac catctctccg tggtaccccg ggtggaactg gtagccatga atgagaccga cccaaagagc atcatcaccc gcatctgtga tctcatgtct gaccggaaga tccagggggt ggtgtttgct gatgacacag accaggaagc catcgcccag atcctcgatt tcatttcagc acagactctc accccgatcc tgggcatcca cgggggctcc tctatgataa tggcagataa ggatgaatcc tccatgttct tccagtttgg cccatcaatt gaacagcaag cttccgtaat gctcaacatc atggaagaat atgactggta catcttttct atcgtcacca cctatttccc tggctaccag gactttgtaa acaagatccg cagcaccatt gagaatagct ttgtgggctg ggagctagag gaggtcctcc tactggacat gtccctggac gatggagatt ctaagatcca gaatcagctc aagaaacttc aaagccccat cattcttctt tactgtacca aggaagaagc cacctacatc tttgaagtgg ccaactcagt agggctgact ggctatggct acacgtggat cgtgcccagt ctggtggcag gggatacaga cacagtgcct gcggagttcc ccactgggct catctctgta tcatatgatg aatgggacta tggcctcccc gccagagtga gagatggaat tgccataatc accactgctg cttctgacat gctgtctgag cacagcttca tccctgagcc caaaagcagt tgttacaaca cccacgagaa gagaatctac cagtccaata tgctaaatag gtatctgatc aatgtcactt ttgaggggag gaatttgtcc ttcagtgaag atggctacca gatgcacccg aaactggtga taattcttct gaacaaggag aggaagtggg aaagggtggg gaagtggaaa gacaagtccc tgcagatgaa gtactatgtg tggccccgaa tgtgtccaga gactgaagag caggaggatg accatctgag cattgtgacc ctggaggagg caccatttgt cattgtggaa agtgtggacc ctctgagtgg aacctgcatg aggaacacag tcccctgcca aaaacgcata gtcactgaga ataaaacaga cgaggagccg ggttacatca aaaaatgctg caaggggttc tgtattgaca tccttaagaa aatttctaaa tctgtgaagt tcacctatga cctttacctg gttaccaatg gcaagcatgg gaagaaaatc aatggaacct ggaatggtat gattggagag gtggtcatga agagggccta catggcagtg ggctcactca ccatcaatga ggaacgatcg gaggtggtcg acttctctgt gcccttcata gagacaggca tcagtgtcat ggtgtcacgc agcaatggga ctgtctcacc ttctgccttc ttagagccat tcagtgctga cgtatgggtg atgatgtttg tgatgctgct catcgtctca gccgtggctg tctttgtctt tgagtacttc agccctgtgg gttataacag gtgcctcgct gatggcagag agcctggtgg accctctttc accatcggca aagctatttg gttgctctgg ggtctggtgt ttaacaactc cgtacctgtg cagaacccaa aggggaccac ctccaagatc atggtgtcag tgtgggcctt ctttgctgtc atcttcctgg ccagctacac tgccaactta gctgccttca tgatccaaga ggaatatgtg gaccaggttt ctggcctgag cgacaaaaag ttccagagac ctaatgactt ctcaccccct ttccgctttg ggaccgtgcc caacggcagc acagagagaa atattcgcaa taactatgca gaaatgcatg cctacatggg aaagttcaac cagaggggtg tagatgatgc attgctctcc ctgaaaacag ggaaactgga tgccttcatc tatgatgcag cagtgctgaa ctatatggca ggcagagatg aaggctgcaa gctggtgacc attggcagtg ggaaggtctt tgcttccact ggctatggca ttgccatcca aaaagattct gggtggaagc gccaggtgga ccttgctatc ctgcagctct ttggagatgg ggagatggaa gaactggaag ctctctggct cactggcatt tgtcacaatg agaagaatga ggtcatgagc agccagctgg acattgacaa catggcaggg gtcttctaca tgttgggggc ggccatggct ctcagcctca tcaccttcat ctgcgaacac cttttctatt ggcagttccg acattgcttt atgggtgtct gttctggcaa gcctggcatg gtcttctcca tcagcagagg tatctacagc tgcatccatg gggtggcgat cgaggagcgc cagtctgtaa tgaactcccc caccgcaacc atgaacaaca cacactccaa catcctgcgc ctgctgcgca cggccaagaa catggctaac ctgtctggtg tgaatggctc accgcagagc gccctggact tcatccgacg ggagtcatcc gtctatgaca tctcagagca ccgccgcagc ttcacgcatt ctgactgcaa atcctacaac aacccgccct gtgaggagaa cctcttcagt gactacatca gtgaggtaga gagaacgttc gggaacctgc agctgaagga cagcaacgtg taccaagatc actaccacca tcaccaccgg ccccatagta ttggcagtgc cagctccatc gatgggctct acgactgtga caacccaccc ttcaccaccc agtccaggtc catcagcaag aagcccctgg acatcggcct cccctcctcc aagcacagcc agctcagtga cctgtacggc aaattctcct tcaagagcga ccgctacagt ggccacgacg acttgatccg ctccgatgtc tctgacatct caacccacac cgtcacctat gggaacatcg agggcaatgc cgccaagagg cgtaagcagc aatataagga cagcctgaag aagcggcctg cctcggccaa gtcccgcagg gagtttgacg agatcgagct ggcctaccgt cgccgaccgc cccgctcccc tgaccacaag cgctacttca gggacaagga agggctacgg gacttctacc tggaccagtt ccgaacaaag gagaactcac cccactggga gcacgtagac ctgaccgaca tctacaagga gcggagtgat gactttaagc gcgactccgt cagcggagga gggccctgta ccaacaggtc tcatatcaag cacgggacgg gcgacaaaca cggcgtggtc agcggggtac ctgcaccttg ggagaagaac ctgaccaacg tggagtggga ggaccggtcc gggggcaact tctgccgcag ctgtccctcc aagctgcaca actactccac gacggtgacg ggtcagaact cgggcaggca ggcgtgcatc cggtgtgagg cttgcaagaa agcaggcaac ctgtatgaca tcagtgagga caactccctg caggaactgg accagccggc tgccccagtg gcggtgacgt caaacgcctc caccactaag taccctcaga gcccgactaa ttccaaggcc cagaagaaga accggaacaa actgcgccgg cagcactcct acgacacctt cgtggacctg cagaaggaag aagccgccct ggccccgcgc agcgtaagcc tgaaagacaa gggccgattc atggatggga gcccctacgc ccacatgttt gagatgtcag ctggcgagag cacctttgcc aacaacaagt cctcagtgcc cactgccgga catcaccacc acaacaaccc cggcggcggg tacatgctca gcaagtcgct ctaccctgac cgggtcacgc aaaacccttt catccccact tttggggacg accagtgctt gctccatggc agcaaatcct acttcttcag gcagcccacg gtggcggggg cgtcgaaagc caggccggac ttccgggccc ttgtcaccaa caagccggtg gtctcggccc ttcatggggc cgtgccagcc cgtttccaga aggacatctg tatagggaac cagtccaacc cctgtgtgcc taacaacaaa aaccccaggg ctttcaatgg ctccagcaat gggcatgttt atgagaaact ttctagtatt gagtctgatg tctga
 OMIM    138252
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 Vector    pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of GRIN2B cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for GRIN2B. It may not necessarily be applicable to this product.
 NCBI GI #    109730560
 NCBI GeneID    2904
 NCBI Accession #    BC113618 [Other Products]
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 UniProt Secondary Accession #    Q12919; Q13220; Q13225; Q14CU4; Q9UM56 [Other Products]
 UniProt Related Accession #    Q13224 [Other Products]
 Molecular Weight    166,367 Da
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 NCBI Official Full Name    Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B, mRNA
 NCBI Official Synonym Full Names    glutamate ionotropic receptor NMDA type subunit 2B
 NCBI Official Symbol    GRIN2B [Similar Products]
 NCBI Official Synonym Symbols   
MRD6; NR2B; hNR3; EIEE27; GluN2B; NMDAR2B
[Similar Products]
 NCBI Protein Information    glutamate receptor ionotropic, NMDA 2B
 UniProt Protein Name    Glutamate receptor ionotropic, NMDA 2B
 UniProt Synonym Protein Names   
Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; NR3; hNR3
 Protein Family    Glutamate receptor ionotropic
 UniProt Gene Name    GRIN2B [Similar Products]
 UniProt Synonym Gene Names    NMDAR2B; GluN2B; NMDAR2B; NR2B; NR3; hNR3 [Similar Products]
 UniProt Entry Name    NMDE2_HUMAN
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 NCBI Summary for GRIN2B    N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GRIN2B    NMDAR2B: an NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death.

Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass; Channel, calcium

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: cell surface; integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; plasma membrane

Molecular Function: glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity; zinc ion binding

Biological Process: ephrin receptor signaling pathway; glutamate signaling pathway; learning and/or memory; MAPKKK cascade; response to ethanol; synaptic transmission; transport

Disease: Epileptic Encephalopathy, Early Infantile, 27; Mental Retardation, Autosomal Dominant 6
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 Research Articles on GRIN2B    1. GluN2B appears to exhibit allosteric regulation/inhibition by two distinct classes of antagonists; data from in silico docking suggest that GluN2B-selective antagonists broadly divide into two distinct classes according to binding pose.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with GRIN2B cdna cloneDiseases associated with GRIN2B cdna clone
 Products by Pathway  Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >36 publications with GRIN2B and Schizophrenia
 Nervous System Diseases Antibodies  >26 publications with GRIN2B and Nervous System Diseases
 Brain Diseases Antibodies  >15 publications with GRIN2B and Brain Diseases
 Substance-Related Disorders Antibodies  >11 publications with GRIN2B and Substance-Related Disorders
 Movement Disorders Antibodies  >9 publications with GRIN2B and Movement Disorders
 Child Development Disorders, Pervasive Antibodies  >8 publications with GRIN2B and Child Development Disorders, Pervasive
 Neoplasms Antibodies  >8 publications with GRIN2B and Neoplasms
 Cognition Disorders Antibodies  >7 publications with GRIN2B and Cognition Disorders
 Anxiety Disorders Antibodies  >7 publications with GRIN2B and Anxiety Disorders
 Epilepsy Antibodies  >6 publications with GRIN2B and Epilepsy
Organs/Tissues associated with GRIN2B cdna clone
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >48 publications with GRIN2B and Brain
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