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H2AFZ cdna clone

Scan QR to view Datasheet Catalog #    MBS1269491 H2AFZ cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

H2AFZ, cDNA Clone

 Also Known As   

H2AFZ cDNA Clone

 Product Gene Name   

H2AFZ cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggctggcg gtaaggctgg aaaggactcc ggaaaggcca agacaaaggc ggtttcccgc tcgcagagag ccggcttgca gttcccagtg ggccgtattc atcgacacct aaaatctagg acgaccagtc atggacgtgt gggcgcgact gccgctgtgt acagcgcagc catcctggag tacctcaccg cagaggtact tgaactggca ggaaatgcat caaaagactt aaaggtaaag cgtattaccc ctcgtcactt gcaacttgct attcgtggag atgaagaatt ggattctctc atcaaggcta caattgctgg tggtggtgtc attccacaca tccacaaatc tctgattggg aagaaaggac aacagaagac tgtctaa
 OMIM    142763
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of H2AFZ cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for H2AFZ. It may not necessarily be applicable to this product.
 NCBI GI #    17389987
 NCBI GeneID    3015
 NCBI Accession #    BC018002 [Other Products]
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 UniProt Secondary Accession #    P17317; Q6I9U0; B2RD56 [Other Products]
 UniProt Related Accession #    P0C0S5 [Other Products]
 Molecular Weight    13,553 Da
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 NCBI Official Full Name    Homo sapiens H2A histone family, member Z, mRNA
 NCBI Official Synonym Full Names    H2A histone family member Z
 NCBI Official Symbol    H2AFZ [Similar Products]
 NCBI Official Synonym Symbols   
H2AZ; H2A.z; H2A/z; H2A.Z-1
[Similar Products]
 NCBI Protein Information    histone H2A.Z
 UniProt Protein Name    Histone H2A.Z
 UniProt Gene Name    H2AFZ [Similar Products]
 UniProt Synonym Gene Names    H2AZ; H2A/z [Similar Products]
 UniProt Entry Name    H2AZ_HUMAN
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 NCBI Summary for H2AFZ    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008]
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 UniProt Comments for H2AFZ    H2AZ: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP. Belongs to the histone H2A family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: Barr body; nuclear heterochromatin; nucleus

Molecular Function: chromatin DNA binding; nucleosomal DNA binding; protein binding

Biological Process: chromatin silencing; positive regulation of transcription from RNA polymerase II promoter
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 Research Articles on H2AFZ    1. H2A.Z removal from chromatin is the primary function of INO80 and ANP32E in promoting homologous recombination.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with H2AFZ cdna cloneDiseases associated with H2AFZ cdna clone
 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway antibodies  Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Meiosis Pathway antibodies  Meiosis Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with H2AFZ and Neoplasms
 Carcinoma Antibodies  >2 publications with H2AFZ and Carcinoma
 Adenocarcinoma Antibodies  >2 publications with H2AFZ and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >1 publications with H2AFZ and Neoplasms, Experimental
 Weight Gain Antibodies  >1 publications with H2AFZ and Weight Gain
 Lung Neoplasms Antibodies  >1 publications with H2AFZ and Lung Neoplasms
 Liver Diseases Antibodies  >1 publications with H2AFZ and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with H2AFZ and Carcinoma, Hepatocellular
 Cell Transformation, Neoplastic Antibodies  >1 publications with H2AFZ and Cell Transformation, Neoplastic
 Adenoma Antibodies  >1 publications with H2AFZ and Adenoma
Organs/Tissues associated with H2AFZ cdna clone
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with H2AFZ and Brain
 Ovary Antibodies  >1 publications with H2AFZ and Ovary
 Vascular Antibodies  >1 publications with H2AFZ and Vascular
 Lung Antibodies  >1 publications with H2AFZ and Lung
 Embryonic Tissue Antibodies  >1 publications with H2AFZ and Embryonic Tissue
 Liver Antibodies  >1 publications with H2AFZ and Liver
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