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HGF cdna clone

Scan QR to view Datasheet Catalog #    MBS1276192 HGF cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HGF, cDNA Clone

★Popular Item★
 Also Known As   

HGF cDNA Clone

 Product Gene Name   

HGF cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgtgggtga ccaaactcct gccagccctg ctgctgcagc atgtcctcct gcatctcctc ctgctcccca tcgccatccc ctatgcagag ggacaaagga aaagaagaaa tacaattcat gaattcaaga aatcagcaaa gactacccta atcaaaatag atccagcact gaagataaaa accaaaaaag tgaatactgc agaccaatgt gctaatagat gtactaggaa taaaggactt ccattcactt gcaaggcttt tgtttttgat aaagcaagaa aacaatgcct ctggttcccc ttcaatagca tgtcaagtgg agtgaaaaaa gaatttggcc atgaatttga cctctatgaa aacaaagact acattagaaa ctgcatcatt ggtaaaggac gcagctacaa gggaacagta tctatcacta agagtggcat caaatgtcag ccctggagtt ccatgatacc acacgaacac agctttttgc cttcgagcta tcggggtaaa gacctacagg aaaactactg tcgaaatcct cgaggggaag aagggggacc ctggtgtttc acaagcaatc cagaggtacg ctacgaagtc tgtgacattc ctcagtgttc agaaggtaaa taa
 OMIM    142409
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of HGF cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for HGF. It may not necessarily be applicable to this product.
 NCBI GI #    39645402
 NCBI GeneID    3082
 NCBI Accession #    BC063485 [Other Products]
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 UniProt Secondary Accession #    Q02935; Q13494; Q14519; Q3KRB2; Q8TCE2; Q9BYL9; Q9BYM0; Q9UDU6; A1L3U6 [Other Products]
 UniProt Related Accession #    P14210 [Other Products]
 Molecular Weight    24,116 Da
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 NCBI Official Full Name    Homo sapiens hepatocyte growth factor (hepapoietin A; scatter factor), mRNA
 NCBI Official Synonym Full Names    hepatocyte growth factor
 NCBI Official Symbol    HGF [Similar Products]
 NCBI Official Synonym Symbols   
SF; HGFB; HPTA; F-TCF; DFNB39
[Similar Products]
 NCBI Protein Information    hepatocyte growth factor
 UniProt Protein Name    Hepatocyte growth factor
 UniProt Synonym Protein Names   
Hepatopoietin-A; Scatter factor; SF
 Protein Family    Hepatocyte growth factor
 UniProt Gene Name    HGF [Similar Products]
 UniProt Synonym Gene Names    HPTA; SF [Similar Products]
 UniProt Entry Name    HGF_HUMAN
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 NCBI Summary for HGF    This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]
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 UniProt Comments for HGF    HGF: HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity. Activating ligand for the receptor tyrosine kinase MET by binding and promoting its dimerization. Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39). A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the peptidase S1 family. Plasminogen subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell development/differentiation; Hormone

Chromosomal Location of Human Ortholog: 7q21.1

Cellular Component: extracellular region; extracellular space; membrane

Molecular Function: chemoattractant activity; protein binding

Biological Process: epithelial to mesenchymal transition; hepatocyte growth factor receptor signaling pathway; negative regulation of caspase activity; platelet degranulation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade

Disease: Deafness, Autosomal Recessive 39
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 Research Articles on HGF    1. The findings suggest that the oncogenic activity of hepsin arises not only from elevated expression level but also from depletion of HAI-1, events which together trigger gain-of-function activity impacting HGF/MET signalling and epithelial cohesion
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with HGF cdna cloneDiseases associated with HGF cdna clone
 Products by Pathway  Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2102 publications with HGF and Neoplasms
 Liver Diseases Antibodies  >668 publications with HGF and Liver Diseases
 Vascular Diseases Antibodies  >525 publications with HGF and Vascular Diseases
 Necrosis Antibodies  >399 publications with HGF and Necrosis
 Neoplasm Invasiveness Antibodies  >391 publications with HGF and Neoplasm Invasiveness
 Liver Neoplasms Antibodies  >386 publications with HGF and Liver Neoplasms
 Fibrosis Antibodies  >375 publications with HGF and Fibrosis
 Inflammation Antibodies  >328 publications with HGF and Inflammation
 Kidney Diseases Antibodies  >277 publications with HGF and Kidney Diseases
 Neoplasms, Experimental Antibodies  >268 publications with HGF and Neoplasms, Experimental
Organs/Tissues associated with HGF cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1623 publications with HGF and Blood
 Liver Antibodies  >1523 publications with HGF and Liver
 Vascular Antibodies  >1063 publications with HGF and Vascular
 Kidney Antibodies  >706 publications with HGF and Kidney
 Bone Antibodies  >652 publications with HGF and Bone
 Lung Antibodies  >588 publications with HGF and Lung
 Muscle Antibodies  >519 publications with HGF and Muscle
 Bone Marrow Antibodies  >456 publications with HGF and Bone Marrow
 Embryonic Tissue Antibodies  >350 publications with HGF and Embryonic Tissue
 Brain Antibodies  >308 publications with HGF and Brain
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