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HLA-DQB1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1270642 HLA-DQB1 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HLA-DQB1, cDNA Clone

 Also Known As   

HLA-DQB1 cDNA Clone

 Product Gene Name   

HLA-DQB1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Application Notes    The full plasmid sequence is not standardly provided for this product. Sequencing report may be available for an additional fee with cDNA product purchase, please inquire.
 Sequence    atgtcttgga agaaggcttt gcggatccct ggaggccttc gggtagcaac tgtgaccttg atgctggcga tgctgagcac cccggtggct gagggcagag actctcccga ggatttcgtg taccagttta agggcatgtg ctacttcacc aacgggacgg agcgcgtgcg tcttgtgacc agatacatct ataaccgaga ggagtacgca cgcttcgaca gcgacgtggg ggtgtatcgg gcggtgacgc cgctggggcc gcctgccgcc gagtactgga acagccagaa ggaagtcctg gagaggaccc gggcggagtt ggacacggtg tgcagacaca actaccagtt ggagctccgc acgaccttgc agcggcgagt ggagcccaca gtgaccatct ccccatccag gacagaggcc ctcaaccacc acaacctgct ggtctgctca gtgacagatt tctatccagc ccagatcaaa gtccggtggt ttcggaatga ccaggaggag acaactggcg ttgtgtccac cccccttatt aggaacggtg actggacctt ccagatcctg gtgatgctgg aaatgactcc ccagcgtgga gacgtctaca cctgccacgt ggagcacccc agcctccaga accccatcat cgtggagtgg cgggctcagt ctgaatctgc ccagagcaag atgctgagtg gcattggagg cttcgtgctg gggctgatct tcctcgggct gggccttatt atccatcaca ggagtcagaa agggctcctg cactga
 OMIM    604305
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of HLA-DQB1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for HLA-DQB1. It may not necessarily be applicable to this product.
 NCBI GI #    15082384
 NCBI GeneID    3119
 NCBI Accession #    BC012106 [Other Products]
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 UniProt Secondary Accession #    A1KR27; A2RPH3; A4Q9R4; A4USG2; A4USG5; A6N8I7; A9YQA0; B0S7Y7; B1A0K6; B1GXI3; B3VLT3 [Other Products]
 UniProt Related Accession #    P01920 [Other Products]
 Molecular Weight    29,991 Da
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 NCBI Official Full Name    Homo sapiens major histocompatibility complex, class II, DQ beta 1, mRNA
 NCBI Official Synonym Full Names    major histocompatibility complex, class II, DQ beta 1
 NCBI Official Symbol    HLA-DQB1 [Similar Products]
 NCBI Official Synonym Symbols   
IDDM1; CELIAC1; HLA-DQB
[Similar Products]
 NCBI Protein Information    HLA class II histocompatibility antigen, DQ beta 1 chain
 UniProt Protein Name    HLA class II histocompatibility antigen, DQ beta 1 chain
 UniProt Synonym Protein Names   
MHC class II antigen DQB1
 Protein Family    HLA class II histocompatibility antigen
 UniProt Gene Name    HLA-DQB1 [Similar Products]
 UniProt Synonym Gene Names    HLA-DQB [Similar Products]
 UniProt Entry Name    DQB1_HUMAN
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 NCBI Summary for HLA-DQB1    HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
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 UniProt Comments for HLA-DQB1    HLA-DQB1: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. Belongs to the MHC class II family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; lysosomal membrane; membrane; MHC class II protein complex; plasma membrane; trans-Golgi network membrane

Molecular Function: peptide antigen binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; humoral immune response mediated by circulating immunoglobulin; immunoglobulin production during immune response; T cell costimulation; T cell receptor signaling pathway

Disease: Celiac Disease; Creutzfeldt-jakob Disease; Multiple Sclerosis, Susceptibility To
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 Research Articles on HLA-DQB1    1. This study findings indicate a possibly increased prevalence of neuromyelitis optica in Muslim Arabs in Israel with distinct (positive and negative) HLA associations.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with HLA-DQB1 cdna cloneDiseases associated with HLA-DQB1 cdna clone
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 1 Antibodies  >501 publications with HLA-DQB1 and Diabetes Mellitus, Type 1
 Nervous System Diseases Antibodies  >340 publications with HLA-DQB1 and Nervous System Diseases
 Narcolepsy Antibodies  >177 publications with HLA-DQB1 and Narcolepsy
 Skin Diseases Antibodies  >171 publications with HLA-DQB1 and Skin Diseases
 Neoplasms Antibodies  >166 publications with HLA-DQB1 and Neoplasms
 Celiac Disease Antibodies  >113 publications with HLA-DQB1 and Celiac Disease
 Multiple Sclerosis Antibodies  >102 publications with HLA-DQB1 and Multiple Sclerosis
 Lung Diseases Antibodies  >98 publications with HLA-DQB1 and Lung Diseases
 Liver Diseases Antibodies  >98 publications with HLA-DQB1 and Liver Diseases
 Necrosis Antibodies  >85 publications with HLA-DQB1 and Necrosis
Organs/Tissues associated with HLA-DQB1 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >653 publications with HLA-DQB1 and Blood
 Pancreas Antibodies  >99 publications with HLA-DQB1 and Pancreas
 Skin Antibodies  >73 publications with HLA-DQB1 and Skin
 Liver Antibodies  >69 publications with HLA-DQB1 and Liver
 Bone Marrow Antibodies  >66 publications with HLA-DQB1 and Bone Marrow
 Thyroid Antibodies  >52 publications with HLA-DQB1 and Thyroid
 Brain Antibodies  >52 publications with HLA-DQB1 and Brain
 Eye Antibodies  >46 publications with HLA-DQB1 and Eye
 Lung Antibodies  >38 publications with HLA-DQB1 and Lung
 Heart Antibodies  >34 publications with HLA-DQB1 and Heart
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