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HMGB2 cdna clone

Scan QR to view Datasheet Catalog #    MBS1269635 HMGB2 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HMGB2, cDNA Clone

★Popular Item★
 Also Known As   

HMGB2 cDNA Clone

 Product Gene Name   

HMGB2 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgggtaaag gagaccccaa caagccgcgg ggcaaaatgt cctcgtacgc cttcttcgtg cagacctgcc gggaagagca caagaagaaa cacccggact cttccgtcaa tttcgcggaa ttctccaaga agtgttcgga gagatggaag accatgtctg caaaggagaa gtcgaagttt gaagatatgg caaaaagtga caaagctcgc tatgacaggg agatgaaaaa ttacgttcct cccaaaggtg ataagaaggg gaagaaaaag gaccccaatg ctcctaaaag gccaccatct gccttcttcc tgttttgctc tgaacatcgc ccaaagatca aaagtgaaca ccctggccta tccattgggg atactgcaaa gaaattgggt gaaatgtggt ctgagcagtc agccaaagat aaacaaccat atgaacagaa agcagctaag ctaaaggaga aatatgaaaa ggatattgct gcatatcgtg ccaagggcaa aagtgaagca ggaaagaagg gccctggcag gccaacaggc tcaaagaaga agaacgaacc agaagatgag gaggaggagg aggaataa
 OMIM    163906
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of HMGB2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for HMGB2. It may not necessarily be applicable to this product.
 NCBI GI #    14705263
 NCBI GeneID    3148
 NCBI Accession #    BC000903 [Other Products]
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 UniProt Secondary Accession #    Q5U072; B2R4K8; D3DP37 [Other Products]
 UniProt Related Accession #    P26583 [Other Products]
 Molecular Weight    24,034 Da
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 NCBI Official Full Name    Homo sapiens high-mobility group box 2, mRNA
 NCBI Official Synonym Full Names    high mobility group box 2
 NCBI Official Symbol    HMGB2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    high mobility group protein B2
 UniProt Protein Name    High mobility group protein B2
 UniProt Synonym Protein Names   
High mobility group protein 2; HMG-2
 Protein Family    High mobility group protein
 UniProt Gene Name    HMGB2 [Similar Products]
 UniProt Synonym Gene Names    HMG2; HMG-2 [Similar Products]
 UniProt Entry Name    HMGB2_HUMAN
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 NCBI Summary for HMGB2    This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HMGB2    HMGB2: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Belongs to the HMGB family.

Protein type: Nuclear receptor co-regulator; DNA-binding

Chromosomal Location of Human Ortholog: 4q31

Cellular Component: cell; condensed chromosome; cytoplasm; extracellular space; nuclear chromatin; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein complex

Molecular Function: chemoattractant activity; damaged DNA binding; DNA bending activity; DNA binding; double-stranded DNA binding; drug binding; four-way junction DNA binding; protein binding; RAGE receptor binding; single-stranded DNA binding; transcription factor activity; transcription factor binding

Biological Process: defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; DNA fragmentation during apoptosis; DNA geometric change; DNA ligation during DNA repair; DNA topological change; inflammatory response to antigenic stimulus; negative regulation of transcription, DNA-dependent; positive regulation of DNA binding; positive regulation of endothelial cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of megakaryocyte differentiation; positive regulation of nuclease activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of neurogenesis; regulation of transcription from RNA polymerase II promoter; response to drug; response to lipopolysaccharide; V(D)J recombination
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 Research Articles on HMGB2    1. Lrp1-antisense directly binds to high-mobility group box 2 (Hmgb2) and inhibits the activity of Hmgb2 to enhance Srebp1a-dependent transcription of Lrp1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with HMGB2 cdna cloneDiseases associated with HMGB2 cdna clone
 Products by Pathway  Pathway Diagram
 Activation Of DNA Fragmentation Factor Pathway antibodies  Activation Of DNA Fragmentation Factor Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Induced DNA Fragmentation Pathway antibodies  Apoptosis Induced DNA Fragmentation Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >32 publications with HMGB2 and Neoplasms
 Inflammation Antibodies  >10 publications with HMGB2 and Inflammation
 Nervous System Diseases Antibodies  >9 publications with HMGB2 and Nervous System Diseases
 Drug Toxicity Antibodies  >8 publications with HMGB2 and Drug Toxicity
 Neoplasms, Experimental Antibodies  >7 publications with HMGB2 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >7 publications with HMGB2 and Disease Models, Animal
 Liver Diseases Antibodies  >6 publications with HMGB2 and Liver Diseases
 Necrosis Antibodies  >6 publications with HMGB2 and Necrosis
 Cardiovascular Diseases Antibodies  >4 publications with HMGB2 and Cardiovascular Diseases
 Liver Neoplasms, Experimental Antibodies  >4 publications with HMGB2 and Liver Neoplasms, Experimental
Organs/Tissues associated with HMGB2 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >54 publications with HMGB2 and Blood
 Thymus Antibodies  >54 publications with HMGB2 and Thymus
 Liver Antibodies  >36 publications with HMGB2 and Liver
 Testis Antibodies  >20 publications with HMGB2 and Testis
 Brain Antibodies  >18 publications with HMGB2 and Brain
 Muscle Antibodies  >12 publications with HMGB2 and Muscle
 Ovary Antibodies  >11 publications with HMGB2 and Ovary
 Lung Antibodies  >9 publications with HMGB2 and Lung
 Spleen Antibodies  >9 publications with HMGB2 and Spleen
 Kidney Antibodies  >7 publications with HMGB2 and Kidney
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