BC024194
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,701 Da
NCBI Official Full Name
Homo sapiens 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1, mRNA
NCBI Official Synonym Full Names
3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1
NCBI Protein Information
3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic
UniProt Protein Name
3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic
UniProt Synonym Protein Names
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1; Endoplasmic reticulum 3-hydroxymethyl-3-methylglutaryl-CoA lyase; er-cHL
UniProt Synonym Gene Names
UniProt Entry Name
HMGC2_HUMAN
UniProt Comments for HMGCLL1
HMGCLL1: Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. Belongs to the HMG-CoA lyase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 4.1.3.4; Lyase
Chromosomal Location of Human Ortholog: 6p12.1
Cellular Component: cytosol; endoplasmic reticulum; membrane; perinuclear region of cytoplasm
Molecular Function: hydroxymethylglutaryl-CoA lyase activity; metal ion binding
Biological Process: ketone body biosynthetic process
Research Articles on HMGCLL1
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Pathways associated with HMGCLL1 cdna clone
Organs/Tissues associated with HMGCLL1 cdna clone
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