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HYOU1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1269943 HYOU1 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HYOU1, cDNA Clone

 Also Known As   

HYOU1 cDNA Clone

 Product Gene Name   

HYOU1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggcagaca aagttaggag gcagaggccg aggaggcgag tctgttgggc cttggtggct gtgctcttgg cagacctgtt ggcactgagt gatacactgg cagtgatgtc tgtggacctg ggcagtgagt ccatgaaggt ggccattgtc aaacctggag tgcccatgga aattgtcttg aataaggaat ctcggaggaa aacaccggtg atcgtgaccc tgaaagaaaa tgaaagattc tttggagaca gtgcagcaag catggcgatt aagaatccaa aggctacgct acgttacttc cagcacctcc tggggaagca ggcagataac ccccatgtag ctctttacca ggcccgcttc ccggagcacg agctgacttt cgacccacag aggcagactg tgcactttca gatcagctcg cagctgcagt tctcacccct gtga
 OMIM    601746
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of HYOU1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for HYOU1. It may not necessarily be applicable to this product.
 NCBI GI #    38197028
 NCBI GeneID    10525
 NCBI Accession #    BC004560 [Other Products]
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 UniProt Secondary Accession #    Q2I204; Q53H25; A8C1Z0; B7Z909 [Other Products]
 UniProt Related Accession #    Q9Y4L1 [Other Products]
 Molecular Weight    62,757 Da
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 NCBI Official Full Name    Homo sapiens hypoxia up-regulated 1, mRNA
 NCBI Official Synonym Full Names    hypoxia up-regulated 1
 NCBI Official Symbol    HYOU1 [Similar Products]
 NCBI Official Synonym Symbols   
Grp170; HSP12A; ORP150; GRP-170; ORP-150
[Similar Products]
 NCBI Protein Information    hypoxia up-regulated protein 1
 UniProt Protein Name    Hypoxia up-regulated protein 1
 UniProt Synonym Protein Names   
150 kDa oxygen-regulated protein; ORP-150; 170 kDa glucose-regulated protein; GRP-170
 Protein Family    Hypoxia up-regulated protein
 UniProt Gene Name    HYOU1 [Similar Products]
 UniProt Synonym Gene Names    GRP170; ORP150; ORP-150; GRP-170 [Similar Products]
 UniProt Entry Name    HYOU1_HUMAN
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 NCBI Summary for HYOU1    The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
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 UniProt Comments for HYOU1    HYOU1: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. Belongs to the heat shock protein 70 family.

Protein type: Heat shock protein; Endoplasmic reticulum; Chaperone

Chromosomal Location of Human Ortholog: 11q23.1-q23.3

Cellular Component: endoplasmic reticulum lumen; extracellular region; focal adhesion; membrane; smooth endoplasmic reticulum

Molecular Function: chaperone binding

Biological Process: ER to Golgi vesicle-mediated transport; receptor-mediated endocytosis
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 Research Articles on HYOU1    1. Two NEFs, Grp170 and Sil1, trigger toxin release from BiP to enable successful retrotranslocation and clarify the fate of the toxin after it disengages from BiP.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with HYOU1 cdna cloneDiseases associated with HYOU1 cdna clone
 Products by Pathway  Pathway Diagram
 Activation Of Chaperone Genes By XBP1(S) Pathway antibodies  Activation Of Chaperone Genes By XBP1(S) Pathway Diagram
 Activation Of Chaperones By IRE1alpha Pathway antibodies  Activation Of Chaperones By IRE1alpha Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Unfolded Protein Response Pathway antibodies  Unfolded Protein Response Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >3 publications with HYOU1 and Neoplasms, Experimental
 Genital Diseases, Male Antibodies  >2 publications with HYOU1 and Genital Diseases, Male
 Disease Models, Animal Antibodies  >2 publications with HYOU1 and Disease Models, Animal
 Fibrosis Antibodies  >2 publications with HYOU1 and Fibrosis
 Nervous System Diseases Antibodies  >2 publications with HYOU1 and Nervous System Diseases
 Proteinuria Antibodies  >1 publications with HYOU1 and Proteinuria
 Liver Diseases Antibodies  >1 publications with HYOU1 and Liver Diseases
 Prostatic Diseases Antibodies  >1 publications with HYOU1 and Prostatic Diseases
 Inflammation Antibodies  >1 publications with HYOU1 and Inflammation
 Necrosis Antibodies  >1 publications with HYOU1 and Necrosis
Organs/Tissues associated with HYOU1 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with HYOU1 and Brain
 Kidney Antibodies  >3 publications with HYOU1 and Kidney
 Blood Antibodies  >2 publications with HYOU1 and Blood
 Connective Tissue Antibodies  >2 publications with HYOU1 and Connective Tissue
 Prostate Antibodies  >2 publications with HYOU1 and Prostate
 Lymph Node Antibodies  >2 publications with HYOU1 and Lymph Node
 Nerve Antibodies  >2 publications with HYOU1 and Nerve
 Lymph Antibodies  >2 publications with HYOU1 and Lymph
 Ovary Antibodies  >1 publications with HYOU1 and Ovary
 Pancreas Antibodies  >1 publications with HYOU1 and Pancreas
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