BC015335
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,630 Da
NCBI Official Full Name
Homo sapiens immature colon carcinoma transcript 1, mRNA
NCBI Official Synonym Full Names
mitochondrial ribosomal protein L58
NCBI Protein Information
peptidyl-tRNA hydrolase ICT1, mitochondrial
UniProt Protein Name
Peptidyl-tRNA hydrolase ICT1, mitochondrial
UniProt Synonym Protein Names
39S ribosomal protein L58, mitochondrial; MRP-L58; Digestion substraction 1; DS-1; Immature colon carcinoma transcript 1 protein
UniProt Synonym Gene Names
UniProt Entry Name
ICT1_HUMAN
NCBI Summary for ICT1
The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
UniProt Comments for ICT1
ICT1: Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. Belongs to the prokaryotic/mitochondrial release factor family. ICT1 subfamily.
Protein type: Mitochondrial; EC 3.1.1.29
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunit; mitochondrial matrix; mitochondrion
Molecular Function: aminoacyl-tRNA hydrolase activity; ribosome binding; translation release factor activity, codon nonspecific; translation release factor activity, codon specific
Research Articles on ICT1
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Organs/Tissues associated with ICT1 cdna clone
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