BC096336
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,240 Da
NCBI Official Full Name
Homo sapiens insulin-degrading enzyme, mRNA
NCBI Official Synonym Full Names
insulin degrading enzyme
NCBI Official Synonym Symbols
NCBI Protein Information
insulin-degrading enzyme
UniProt Protein Name
Insulin-degrading enzyme
UniProt Synonym Protein Names
Abeta-degrading protease; Insulin protease; Insulinase; Insulysin
UniProt Synonym Gene Names
UniProt Entry Name
IDE_HUMAN
NCBI Summary for IDE
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
UniProt Comments for IDE
IDE: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. Belongs to the peptidase M16 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; Nuclear receptor co-regulator; EC 3.4.24.56; Cell surface
Chromosomal Location of Human Ortholog: 10q23-q25
Cellular Component: cell surface; cytoplasm; cytosol; extracellular space; mitochondrion; nucleoplasm; nucleus; peroxisomal matrix; peroxisome
Molecular Function: ATP binding; glycoprotein binding; insulin binding; metalloendopeptidase activity; peptide binding; protein binding; protein homodimerization activity; receptor binding; ubiquitin binding; zinc ion binding
Biological Process: beta-amyloid metabolic process; determination of adult life span; positive regulation of protein oligomerization; protein homooligomerization; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with IDE cdna clone
Diseases associated with IDE cdna clone
Organs/Tissues associated with IDE cdna clone
|