BC005247
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,485 Da
NCBI Official Full Name
Homo sapiens isopentenyl-diphosphate delta isomerase 1, mRNA
NCBI Official Synonym Full Names
isopentenyl-diphosphate delta isomerase 1
NCBI Official Synonym Symbols
NCBI Protein Information
isopentenyl-diphosphate Delta-isomerase 1
UniProt Protein Name
Isopentenyl-diphosphate Delta-isomerase 1
UniProt Synonym Protein Names
Isopentenyl pyrophosphate isomerase 1; IPP isomerase 1; IPPI1
UniProt Synonym Gene Names
UniProt Entry Name
IDI1_HUMAN
NCBI Summary for IDI1
IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]
UniProt Comments for IDI1
IDI1: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Belongs to the IPP isomerase type 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; EC 5.3.3.2; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Isomerase
Chromosomal Location of Human Ortholog: 10p15.3
Cellular Component: cytosol; peroxisome
Biological Process: cholesterol biosynthetic process
Research Articles on IDI1
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Pathways associated with IDI1 cdna clone
Diseases associated with IDI1 cdna clone
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