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IFIT3 cdna clone

Scan QR to view Datasheet Catalog #    MBS1267508 IFIT3 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IFIT3, cDNA Clone

★Popular Item★
 Also Known As   

IFIT3 cDNA Clone

 Product Gene Name   

IFIT3 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgagtgagg tcaccaagaa ttccctggag aaaatccttc cacagctgaa atgccatttc acctggaact tattcaagga agacagtgtc tcaagggatc tagaagatag agtgtgtaac cagattgaat ttttaaacac tgagttcaaa gctacaatgt acaacttgtt ggcctacata aaacacctag atggtaacaa cgaggcagcc ctggaatgct tacggcaagc tgaagagtta atccagcaag aacatgctga ccaagcagaa atcagaagtc tagtcacttg gggaaactac gcctgggtct actatcactt gggcagactc tcagatgctc agatttatgt agataaggtg aaacaaacct gcaagaaatt ttcaaatcca tacagtattg agtattctga acttgactgt gaggaagggt ggacacaact gaagtgtgga agaaatgaaa gggcgaaggt gtgttttgag aaggctctgg aagaaaagcc caacaaccca gaattctcct ctggactggc aattgcgatg taccatctgg ataatcaccc agagaaacag ttctctactg atgttttgaa gcaggccatt gagctgagtc ctgataacca atacgtcaag gttctcttgg gcctgaaact gcagaagatg aataaagaag ctgaaggaga gcagtttgtt gaagaagcct tggaaaagtc tccttgccaa acagatgtcc tccgcagtgc agccaaattt tacagaagaa aaggtgacct agacaaagct attgaactgt ttcaacgggt gttggaatcc acaccaaaca atggctacct ctatcaccag attgggtgct gctacaaggc aaaagtaaga caaatgcaga atacaggaga atctgaagct agtggaaata aagagatgat tgaagcacta aagcaatatg ctatggacta ttcgaataaa gctcttgaga agggactgaa tcctctgaat gcatactccg atctcgctga gttcctggag acggaatgtt atcagacacc attcaataag gaagtccctg atgctgaaaa gcaacaatcc catcagcgct actgcaacct tcagaaatat aatgggaagt ctgaagacac tgctgtgcaa catggtttag agggtttgtc cataagcaaa aaatcaactg acaaggaaga gatcaaagac caaccacaga atgtatctga aaatctgctt ccacaaaatg caccaaatta ttggtatctt caaggattaa ttcataagca gaatggagat ctgctgcaag cagccaaatg ttatgagaag gaactgggcc gcctgctaag ggatgcccct tcaggcatag gcagtatttt cctgtcagca tctgagcttg aggatggtag tgaggaaatg ggccagggcg cagtcagctc cagtcccaga gagctcctct ctaactcaga gcaactgaac tga
 OMIM    604650
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of IFIT3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for IFIT3. It may not necessarily be applicable to this product.
 NCBI GI #    33876133
 NCBI GeneID    3437
 NCBI Accession #    BC001383 [Other Products]
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 UniProt Secondary Accession #    Q99634; Q9BSK7 [Other Products]
 UniProt Related Accession #    O14879 [Other Products]
 Molecular Weight    55,985 Da
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 NCBI Official Full Name    Homo sapiens interferon-induced protein with tetratricopeptide repeats 3, mRNA
 NCBI Official Synonym Full Names    interferon induced protein with tetratricopeptide repeats 3
 NCBI Official Symbol    IFIT3 [Similar Products]
 NCBI Official Synonym Symbols   
P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; cig41; CIG-49; GARG-49
[Similar Products]
 NCBI Protein Information    interferon-induced protein with tetratricopeptide repeats 3
 UniProt Protein Name    Interferon-induced protein with tetratricopeptide repeats 3
 UniProt Synonym Protein Names   
CIG49; ISG-60; Interferon-induced 60 kDa protein; IFI-60K; Interferon-induced protein with tetratricopeptide repeats 4; IFIT-4; Retinoic acid-induced gene G protein; P60; RIG-G
 Protein Family    Interferon-induced protein with tetratricopeptide repeats
 UniProt Gene Name    IFIT3 [Similar Products]
 UniProt Synonym Gene Names    CIG-49; IFI60; IFIT4; ISG60; IFIT-3; IFI-60K; IFIT-4; P60; RIG-G [Similar Products]
 UniProt Entry Name    IFIT3_HUMAN
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 UniProt Comments for IFIT3    IFIT3: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. Belongs to the IFIT family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: cytoplasm; cytosol; mitochondrion

Molecular Function: identical protein binding; protein binding; RNA binding

Biological Process: defense response to virus; negative regulation of apoptosis; negative regulation of cell proliferation; response to virus
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 Research Articles on IFIT3    1. results indicated that RIG-G level was high in maturated cells and low in blast cells, and suggested that RIG-G might play a role in the differentiation of bone marrow hemocytes in vivo
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with IFIT3 cdna cloneDiseases associated with IFIT3 cdna clone
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >10 publications with IFIT3 and Neoplasms
 Nervous System Diseases Antibodies  >7 publications with IFIT3 and Nervous System Diseases
 Inflammation Antibodies  >3 publications with IFIT3 and Inflammation
 Liver Diseases Antibodies  >2 publications with IFIT3 and Liver Diseases
 Necrosis Antibodies  >2 publications with IFIT3 and Necrosis
 Carcinoma Antibodies  >1 publications with IFIT3 and Carcinoma
 Atherosclerosis Antibodies  >1 publications with IFIT3 and Atherosclerosis
 Carcinoma, Hepatocellular Antibodies  >1 publications with IFIT3 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >1 publications with IFIT3 and Neoplasms, Experimental
Organs/Tissues associated with IFIT3 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with IFIT3 and Blood
 Brain Antibodies  >6 publications with IFIT3 and Brain
 Kidney Antibodies  >3 publications with IFIT3 and Kidney
 Muscle Antibodies  >2 publications with IFIT3 and Muscle
 Lung Antibodies  >2 publications with IFIT3 and Lung
 Liver Antibodies  >2 publications with IFIT3 and Liver
 Lymph Node Antibodies  >1 publications with IFIT3 and Lymph Node
 Bone Marrow Antibodies  >1 publications with IFIT3 and Bone Marrow
 Mouth Antibodies  >1 publications with IFIT3 and Mouth
 Vascular Antibodies  >1 publications with IFIT3 and Vascular
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