BC001383
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,985 Da
NCBI Official Full Name
Homo sapiens interferon-induced protein with tetratricopeptide repeats 3, mRNA
NCBI Official Synonym Full Names
interferon induced protein with tetratricopeptide repeats 3
NCBI Official Synonym Symbols
P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; cig41; CIG-49; GARG-49 [Similar Products]
NCBI Protein Information
interferon-induced protein with tetratricopeptide repeats 3
UniProt Protein Name
Interferon-induced protein with tetratricopeptide repeats 3
UniProt Synonym Protein Names
CIG49; ISG-60; Interferon-induced 60 kDa protein; IFI-60K; Interferon-induced protein with tetratricopeptide repeats 4; IFIT-4; Retinoic acid-induced gene G protein; P60; RIG-G
UniProt Synonym Gene Names
CIG-49; IFI60; IFIT4; ISG60; IFIT-3; IFI-60K; IFIT-4; P60; RIG-G [Similar Products]
UniProt Entry Name
IFIT3_HUMAN
UniProt Comments for IFIT3
IFIT3: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. Belongs to the IFIT family.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 10q24
Cellular Component: cytoplasm; cytosol; mitochondrion
Molecular Function: identical protein binding; protein binding; RNA binding
Biological Process: defense response to virus; negative regulation of apoptosis; negative regulation of cell proliferation; response to virus
Research Articles on IFIT3
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Pathways associated with IFIT3 cdna clone
Diseases associated with IFIT3 cdna clone
Organs/Tissues associated with IFIT3 cdna clone
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