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IGHG1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1269210 IGHG1 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $285 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IGHG1, cDNA Clone

 Also Known As   

IGHG1 cDNA Clone

 Product Gene Name   

IGHG1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag gcgcagttgg tggagtctgg gggaggcgtg gtccagcccg ggagctccct gagactctcc tgtgcagcct ctggtttcag gttcagcaat tatggcatgc actgggtccg ccaggctcca ggcaaggggc tggagtgggt ggcagttttt tcatatgatg aaagtgataa atattatgca gcctccgtga agggtcgatt taccatctcc agagacaact ccaagaacac gttgtctctg caaatgaaca gcctgagagt tgaggacacg gctgtttact actgtgcgaa agatcagaag ccctggtaca gcaacagctg gtttctaacc aactttgact cttggggccg gggcaccctg gtcaccgtct cctcagcctc caccaagggc ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc ctgtctccgg agctgcaact ggaggagagc tgtgcggagg cgcaggacgg ggagctggac gggctgtgga cgaccatcac catcttcatc acactcttcc tgttaagcgt gtgctacagt gccaccgtca ccttcttcaa ggtgaagtgg atcttctcct cggtggtgga cctgaagcag accatcatcc ccgactacag gaacatgatc ggacaggggg cctag
 Chromosome Location    Chromosome: 14; NC_000014.8 (106207810..106209407, complement). Location: 14q32.33
 OMIM    147100
 3D Structure    ModBase 3D Structure for P01857
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of IGHG1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for IGHG1. It may not necessarily be applicable to this product.
 NCBI GI #    33879071
 NCBI GeneID    3500
 NCBI Accession #    BC019046 [Other Products]
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 UniProt Primary Accession #    P01857 [Other Products]
 UniProt Related Accession #    P01857 [Other Products]
 Molecular Weight    36,106 Da
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 NCBI Official Full Name    Homo sapiens immunoglobulin heavy constant gamma 1 (G1m marker), mRNA
 NCBI Official Synonym Full Names    immunoglobulin heavy constant gamma 1 (G1m marker)
 NCBI Official Symbol    IGHG1 [Similar Products]
 UniProt Protein Name    Ig gamma-1 chain C region
 Protein Family    Ig gamma-1 chain C region
 UniProt Gene Name    IGHG1 [Similar Products]
 UniProt Entry Name    IGHG1_HUMAN
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 UniProt Comments for IGHG1    IGHG1: Defects in IGHG1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

Protein type: Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; antigen binding

Biological Process: innate immune response; complement activation, classical pathway; complement activation

Disease: Myeloma, Multiple
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 Research Articles on IGHG1    1. Suppression of IGHG1 gene expression by siRNA leads to growth inhibition and apoptosis induction in human prostate cancer cell.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with IGHG1 cdna clone
 Products by Pathway  Pathway Diagram
 Classical Antibody-mediated Complement Activation Pathway antibodies  Classical Antibody-mediated Complement Activation Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway antibodies  Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway Diagram
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