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IL2 cdna clone

Scan QR to view Datasheet Catalog #    MBS1267020 IL2 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL2, cDNA Clone

★Popular Item★
 Also Known As   

IL2 cDNA Clone

 Product Gene Name   

IL2 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga tggattacct tttgtcaaag catcatctca acactgactt ga
 OMIM    147680
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of IL2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for IL2. It may not necessarily be applicable to this product.
 NCBI GI #    42542684
 NCBI GeneID    3558
 NCBI Accession #    BC066257 [Other Products]
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 UniProt Secondary Accession #    P01585 [Other Products]
 UniProt Related Accession #    P60568 [Other Products]
 Molecular Weight    17,628 Da
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 NCBI Official Full Name    Homo sapiens interleukin 2, mRNA
 NCBI Official Synonym Full Names    interleukin 2
 NCBI Official Symbol    IL2 [Similar Products]
 NCBI Official Synonym Symbols   
IL-2; TCGF; lymphokine
[Similar Products]
 NCBI Protein Information    interleukin-2
 UniProt Protein Name    Interleukin-2
 UniProt Synonym Protein Names   
T-cell growth factor; TCGF; INN: Aldesleukin
 Protein Family    Interleukin
 UniProt Gene Name    IL2 [Similar Products]
 UniProt Synonym Gene Names    IL-2; TCGF [Similar Products]
 UniProt Entry Name    IL2_HUMAN
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 NCBI Summary for IL2    The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL2    IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family.

Protein type: Secreted; Cytokine; Secreted, signal peptide; Oncoprotein

Chromosomal Location of Human Ortholog: 4q26-q27

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; growth factor activity; interleukin-2 receptor binding; kinase activator activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: cell adhesion; cell-cell signaling; immune response; MAPKKK cascade; natural killer cell activation; negative regulation of apoptosis; negative regulation of B cell apoptosis; positive regulation of activated T cell proliferation; positive regulation of B cell proliferation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of inflammatory response; positive regulation of interleukin-17 production; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat5 protein; T cell differentiation
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 Research Articles on IL2    1. There was a significant association of IL2 rs6534349 polymorphism with increased asthma risk and high load M. pneumoniae infectionin the GG genotype. IL-2 serum expression levels were significantly higher in M. pneumoniae negative subjects.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with IL2 cdna cloneDiseases associated with IL2 cdna clone
 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >771 publications with IL2 and Neoplasms
 Necrosis Antibodies  >273 publications with IL2 and Necrosis
 Leukemia Antibodies  >212 publications with IL2 and Leukemia
 Inflammation Antibodies  >155 publications with IL2 and Inflammation
 Neoplasms, Experimental Antibodies  >138 publications with IL2 and Neoplasms, Experimental
 Melanoma Antibodies  >124 publications with IL2 and Melanoma
 Kidney Diseases Antibodies  >102 publications with IL2 and Kidney Diseases
 Drug Toxicity Antibodies  >96 publications with IL2 and Drug Toxicity
 Liver Diseases Antibodies  >88 publications with IL2 and Liver Diseases
 Kidney Neoplasms Antibodies  >67 publications with IL2 and Kidney Neoplasms
Organs/Tissues associated with IL2 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2041 publications with IL2 and Blood
 Uncharacterized Tissue Antibodies  >1 publications with IL2 and Uncharacterized Tissue
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