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IMPDH2 cdna clone

Scan QR to view Datasheet Catalog #    MBS1273729 IMPDH2 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IMPDH2, cDNA Clone

★Popular Item★
 Also Known As   

IMPDH2 cDNA Clone

 Product Gene Name   

IMPDH2 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggccgact acctgattag tgggggcacg tcctacgtgc cagacgacgg actcacagca cagcagctct tcaactgcgg agacggcctc acctacaatg actttctcat tctccctggg tacatcgact tcactgcaga ccaggtggac ctgacttctg ctctgaccaa gaaaatcact cttaagaccc cactggtttc ctctcccatg gacacagtca cagaggctgg gatggccata gcaatggcgc ttacaggcgg tattggcttc atccaccaca actgtacacc tgaattccag gccaatgaag ttcggaaagt gaagaaatat gaacagggat tcatcacaga ccctgtggtc ctcagcccca aggatcgcgt gcgggatgtt tttgaggcca aggcccggca tggtttctgc ggtatcccaa tcacagacac aggccggatg gggagccgct tggtgggcat catctcctcc agggacattg attttctcaa agaggaggaa catgactgtt tcttggaaga gataatgaca aagagggaag acttggtggt agcccctgca ggcatcacac tgaaggaggc aaatgaaatt ctgcagcgca gcaagaaggg aaagttgccc attgtaaatg aagatgatga gcttgtggcc atcattgccc ggacagacct gaagaagaat cgggactacc cactagcctc caaagatgcc aagaaacagc tgctgtgtgg ggcagccatt ggcactcatg aggatgacaa gtataggctg gacttgctcg cccaggctgg tgtggatgta gtggttttgg actcttccca gggaaattcc atcttccaga tcaatatgat caagtacatc aaagacaaat accctaatct ccaagtcatt ggaggcaatg tggtcactgc tgcccaggcc aagaacctca ttgatgcagg tgtggatgcc ctgcgggtgg gcatgggaag tggctccatc tgcattacgc aggaagtgct ggcctgtggg cggccccaag caacagcagt gtacaaggtg tcagagtatg cacggcgctt tggtgttccg gtcattgctg atggaggaat ccaaaatgtg ggtcatattg cgaaagcctt ggcccttggg gcctccacag tcatgatggg ctctctcctg gctgccacca ctgaggcccc tggtgaatac ttcttttccg atgggatccg gctaaagaaa tatcgcggta tgggttctct cgatgccatg gacaagcacc tcagcagcca gaacagatat ttcagtgaag ctgacaaaat caaagtggcc cagggagtgt ctggtgctgt gcaggacaaa gggtcaatcc acaaatttgt cccttacctg attgctggca tccaacactc atgccaggac attggtgcca agagcttgac ccaagtccga gccatgatgt actctgggga gcttaagttt gagaagagaa cgtcctcagc ccaggtggaa ggtggcgtcc atagcctcca ttcgtatgag aagcggcttt tctga
 OMIM    146691
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of IMPDH2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for IMPDH2. It may not necessarily be applicable to this product.
 NCBI GI #    13543972
 NCBI GeneID    3615
 NCBI Accession #    BC006124 [Other Products]
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 UniProt Secondary Accession #    Q6LEF3 [Other Products]
 UniProt Related Accession #    P12268 [Other Products]
 Molecular Weight    55,805 Da
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 NCBI Official Full Name    Homo sapiens IMP (inosine monophosphate) dehydrogenase 2, mRNA
 NCBI Official Synonym Full Names    inosine monophosphate dehydrogenase 2
 NCBI Official Symbol    IMPDH2 [Similar Products]
 NCBI Official Synonym Symbols   
IMPD2; IMPDH-II
[Similar Products]
 NCBI Protein Information    inosine-5'-monophosphate dehydrogenase 2
 UniProt Protein Name    Inosine-5'-monophosphate dehydrogenase 2
 UniProt Synonym Protein Names   
IMPDH-II
 UniProt Gene Name    IMPDH2 [Similar Products]
 UniProt Synonym Gene Names    IMP dehydrogenase 2; IMPD 2; IMPDH 2 [Similar Products]
 UniProt Entry Name    IMDH2_HUMAN
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 NCBI Summary for IMPDH2    This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IMPDH2    IMPDH2: a rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.

Protein type: EC 1.1.1.205; Nucleotide Metabolism - purine; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: cytoplasm; cytosol; membrane; nucleus; peroxisomal membrane

Molecular Function: IMP dehydrogenase activity; nucleotide binding; protein binding

Biological Process: GTP biosynthetic process; purine ribonucleoside monophosphate biosynthetic process
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 Research Articles on IMPDH2    1. The findings suggest that overexpressed IMPDH2 can be used as a biomarker for kidney and bladder cancer diagnosis and is a potential therapeutic target for the diseases
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with IMPDH2 cdna cloneDiseases associated with IMPDH2 cdna clone
 Products by Pathway  Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Ribonucleoside Monophosphate Biosynthesis Pathway antibodies  Purine Ribonucleoside Monophosphate Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >15 publications with IMPDH2 and Neoplasms
 Leukemia Antibodies  >3 publications with IMPDH2 and Leukemia
 Drug Toxicity Antibodies  >3 publications with IMPDH2 and Drug Toxicity
 Kidney Diseases Antibodies  >3 publications with IMPDH2 and Kidney Diseases
 Inflammation Antibodies  >2 publications with IMPDH2 and Inflammation
 Neoplasm Metastasis Antibodies  >2 publications with IMPDH2 and Neoplasm Metastasis
 Carcinoma Antibodies  >2 publications with IMPDH2 and Carcinoma
 Liver Diseases Antibodies  >2 publications with IMPDH2 and Liver Diseases
 Nausea Antibodies  >1 publications with IMPDH2 and Nausea
 Fibrosis Antibodies  >1 publications with IMPDH2 and Fibrosis
Organs/Tissues associated with IMPDH2 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with IMPDH2 and Blood
 Kidney Antibodies  >15 publications with IMPDH2 and Kidney
 Liver Antibodies  >4 publications with IMPDH2 and Liver
 Pancreas Antibodies  >2 publications with IMPDH2 and Pancreas
 Heart Antibodies  >2 publications with IMPDH2 and Heart
 Eye Antibodies  >2 publications with IMPDH2 and Eye
 Bone Antibodies  >2 publications with IMPDH2 and Bone
 Stomach Antibodies  >1 publications with IMPDH2 and Stomach
 Prostate Antibodies  >1 publications with IMPDH2 and Prostate
 Uterus Antibodies  >1 publications with IMPDH2 and Uterus
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