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ITPK1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1275773 ITPK1 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ITPK1, cDNA Clone

 Also Known As   

ITPK1 cDNA Clone

 Product Gene Name   

ITPK1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgcagacct ttctgaaagg gaagagagtt ggctactggc tgagcgagaa gaaaatcaag aagctgaatt tccaggcctt cgccgagctg tgcaggaagc gagggatgga ggttgtgcag ctgaacctta gccggccgat cgaggagcag ggccccctgg acgtcatcat ccacaagctg actgacgtca tccttgaagc cgaccagaat gatagccagt ccctggagct ggtgcacagg ttccaggagt acatcgatgc ccaccctgag accatcgtcc tggacccgct ccctgccatc agaaccctgc ttgaccgctc caagtcctat gagctcatcc ggaagattga ggcctacatg gaagacgaca ggatctgctc gccacccttc atggagctca cgagcctgtg cggggatgac accatgcggc tgctggagaa gaacggcttg actttcccat tcatttgcaa aaccagagtg gctcatggca ccaactctca cgagatggct atcgtgttca accaggaggg cctgaacgcc atccagccac cctgcgtggt ccagaatttc atcaaccaca acgccgtcct gtacaaggtg ttcgtggttg gcgagtccta caccgtggtc cagaggccct cactcaagaa cttctccgca ggcacatcag accgtgagtc catcttcttc aacagccaca acgtgtcaaa gccggagtcg tcatcggtcc tgacggagct ggacaagatc gagggcgtgt tcgagcggcc gagcgacgag gtcatccggg agctctcccg ggccctgcgg caggcactgg gcgtgtcact cttcggcatc gacatcatca tcaacaacca gacagggcag cacgccgtca ttgacatcaa tgccttccca ggctacgagg gcgtgagcga gttcttcaca gacctcctga accacatcgc cactgtcctg cagggccaga gcacagccat ggcagccaca ggggacgtgg ccctgctgag gcacagcaag cttctggccg agccggcggg cggcctggtg ggcgagcgga catgcagcgc cagccccggc tgctgcggca gcatgatggg ccaggacgcg ccctggaagg ctgaggccga cgcgggcggc accgccaagc tgccgcacca gagactcggc tgcaacgccg gcgtgtcgcc cagcttccag cagcattgtg tggcctccct ggccaccaag gcctcctccc agtag
 OMIM    601838
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ITPK1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ITPK1. It may not necessarily be applicable to this product.
 NCBI GI #    17390428
 NCBI GeneID    3705
 NCBI Accession #    BC018192 [Other Products]
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 UniProt Secondary Accession #    Q9BTL6; Q9H2E7 [Other Products]
 UniProt Related Accession #    Q13572 [Other Products]
 Molecular Weight    35,632 Da
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 NCBI Official Full Name    Homo sapiens inositol 1,3,4-triphosphate 5/6 kinase, mRNA
 NCBI Official Synonym Full Names    inositol-tetrakisphosphate 1-kinase
 NCBI Official Symbol    ITPK1 [Similar Products]
 NCBI Official Synonym Symbols   
ITRPK1
[Similar Products]
 NCBI Protein Information    inositol-tetrakisphosphate 1-kinase
 UniProt Protein Name    Inositol-tetrakisphosphate 1-kinase
 UniProt Synonym Protein Names   
Inositol 1,3,4-trisphosphate 5/6-kinase (EC:2.7.1.159); Inositol-triphosphate 5/6-kinase; Ins(1,3,4)P(3) 5/6-kinase
 Protein Family    Inositol-tetrakisphosphate 1-kinase
 UniProt Gene Name    ITPK1 [Similar Products]
 UniProt Synonym Gene Names    Inositol-triphosphate 5/6-kinase; Ins(1,3,4)P(3) 5/6-kinase [Similar Products]
 UniProt Entry Name    ITPK1_HUMAN
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 NCBI Summary for ITPK1    This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016]
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 UniProt Comments for ITPK1    ITPK1: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. Belongs to the ITPK1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.1.159; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.134; Kinase, lipid; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q31

Cellular Component: cytosol

Molecular Function: catalytic activity; inositol tetrakisphosphate 1-kinase activity

Biological Process: blood coagulation; inositol phosphate metabolic process; signal transduction
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 Research Articles on ITPK1    1. The results suggested that the maternal rs3783903 of ITPK1 might be associated with spina bifida, and the allele G of rs3783903 might affect the binding of AP-1 and the decrease of maternal plasma inositol hexakisphosphate concentration.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ITPK1 cdna cloneDiseases associated with ITPK1 cdna clone
 Products by Pathway  Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis V (from Ins(1,3,4)P3) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis V (from Ins(1,3,4)P3) Pathway Diagram
 D-myo-inositol (1,4,5,6)-tetrakisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5,6)-tetrakisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (1,4,5,6)-tetrakisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5,6)-tetrakisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with ITPK1 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >2 publications with ITPK1 and Congenital Abnormalities
 Nervous System Malformations Antibodies  >2 publications with ITPK1 and Nervous System Malformations
 Disorders of Sex Development Antibodies  >1 publications with ITPK1 and Disorders of Sex Development
Organs/Tissues associated with ITPK1 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >1 publications with ITPK1 and Thyroid
 Blood Antibodies  >1 publications with ITPK1 and Blood
 Muscle Antibodies  >1 publications with ITPK1 and Muscle
 Embryonic Tissue Antibodies  >1 publications with ITPK1 and Embryonic Tissue
 Lung Antibodies  >1 publications with ITPK1 and Lung
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