BC011865
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,745 Da
NCBI Official Full Name
Homo sapiens junction plakoglobin, mRNA
NCBI Official Synonym Full Names
junction plakoglobin
NCBI Official Synonym Symbols
DP3; PDGB; PKGB; CTNNG; DPIII; ARVD12 [Similar Products]
NCBI Protein Information
junction plakoglobin
UniProt Protein Name
Junction plakoglobin
UniProt Synonym Protein Names
Catenin gamma; Desmoplakin III; Desmoplakin-3
UniProt Synonym Gene Names
UniProt Entry Name
PLAK_HUMAN
NCBI Summary for JUP
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]
UniProt Comments for JUP
CTNNG: Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Homodimer. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma- catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSC2. Belongs to the beta-catenin family.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: catenin complex; cell-cell adherens junction; cytoplasm; cytoskeleton; cytosol; desmosome; extracellular matrix; focal adhesion; hemidesmosome; intercellular junction; internal side of plasma membrane; nucleus; plasma membrane; zonula adherens
Molecular Function: alpha-catenin binding; cadherin binding; cell adhesion molecule binding; protein binding; protein homodimerization activity; protein phosphatase binding; structural constituent of cell wall; transcription coactivator activity
Biological Process: cell migration; cell-cell adhesion; detection of mechanical stimulus; positive regulation of protein import into nucleus; positive regulation of transcription factor activity; regulation of cell proliferation
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 12; Naxos Disease
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Pathways associated with JUP cdna clone
Diseases associated with JUP cdna clone
Organs/Tissues associated with JUP cdna clone
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