BC082762
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
90,044 Da
NCBI Official Full Name
Homo sapiens KN motif and ankyrin repeat domains 2, mRNA
NCBI Official Synonym Full Names
KN motif and ankyrin repeat domains 2
NCBI Protein Information
KN motif and ankyrin repeat domain-containing protein 2
UniProt Protein Name
KN motif and ankyrin repeat domain-containing protein 2
UniProt Synonym Protein Names
Ankyrin repeat domain-containing protein 25; Matrix-remodeling-associated protein 3; SRC-1-interacting protein; SIP; SRC-interacting protein; SRC1-interacting protein
UniProt Synonym Gene Names
ANKRD25; KIAA1518; MXRA3; SIP; SIP; SRC-interacting protein; SRC1-interacting protein [Similar Products]
UniProt Entry Name
KANK2_HUMAN
NCBI Summary for KANK2
This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul 2016]
UniProt Comments for KANK2
ANKRD25: a mammalian growth regulatory protein containing five Ankyrin repeats, common protein-protein interaction motifs. Ankyrin repeats are found in proteins with diverse functions including transcriptional initiators, cell-cycle regulators, cytoskeletal, and ion transporters. Three alternatively spliced isoforms have been described.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: cytoplasm; mitochondrion
Molecular Function: protein binding
Biological Process: negative regulation of cell proliferation; negative regulation of estrogen receptor signaling pathway; negative regulation of programmed cell death; negative regulation of transcription from RNA polymerase II promoter
Disease: Palmoplantar Keratoderma And Woolly Hair
Research Articles on KANK2
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Organs/Tissues associated with KANK2 cdna clone
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