BC004132
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
71,497 Da
NCBI Official Full Name
Homo sapiens lysyl-tRNA synthetase, mRNA
NCBI Official Synonym Full Names
lysyl-tRNA synthetase
NCBI Official Synonym Symbols
KRS; KARS1; KARS2; CMTRIB; DFNB89 [Similar Products]
NCBI Protein Information
lysine--tRNA ligase
UniProt Protein Name
Lysine--tRNA ligase
UniProt Synonym Protein Names
Lysyl-tRNA synthetase; LysRS
UniProt Synonym Gene Names
UniProt Entry Name
SYK_HUMAN
NCBI Summary for KARS
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for KARS
KARS: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate (Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. Homodimer; also part of a multisubunit complex that groups AIMP1, AIMP2, EEF1A1 and tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro. Interacts with AIMP2 (via N- terminus) and MITF. Interacts directly with HIV-1 virus GAG protein. Up-regulated by DARS and EEF1A1, but not by AIMP2. Belongs to the class-II aminoacyl-tRNA synthetase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Translation; Mitochondrial; Ligase; EC 6.1.1.6
Chromosomal Location of Human Ortholog: 16q23.1
Cellular Component: cytoplasm; cytosol; microtubule cytoskeleton; mitochondrial matrix; mitochondrion
Molecular Function: lysine-tRNA ligase activity; protein binding
Biological Process: lysyl-tRNA aminoacylation; tRNA aminoacylation for protein translation
Disease: Charcot-marie-tooth Disease, Recessive Intermediate B; Deafness, Autosomal Recessive 89
Research Articles on KARS
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Pathways associated with KARS cdna clone
Diseases associated with KARS cdna clone
Organs/Tissues associated with KARS cdna clone
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