BC117167
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,292 Da
NCBI Official Full Name
Homo sapiens K(lysine) acetyltransferase 5, mRNA
NCBI Official Synonym Full Names
lysine acetyltransferase 5
NCBI Official Synonym Symbols
TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; ZC2HC5; HTATIP1 [Similar Products]
NCBI Protein Information
histone acetyltransferase KAT5
UniProt Protein Name
Histone acetyltransferase KAT5
UniProt Synonym Protein Names
60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting protein
UniProt Synonym Gene Names
UniProt Entry Name
KAT5_HUMAN
NCBI Summary for KAT5
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Comments for KAT5
Tip60: a histone acetyl transferase (HAT) of the MYST family. Originally isolated as an HIV-1 TAT-interactive protein. Plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating nuclear proteins. Plays a role in DNA repair and apoptosis. Three splice variants have been described.
Protein type: Nuclear receptor co-regulator; Acetyltransferase; EC 2.3.1.48; Nucleolus
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: NuA4 histone acetyltransferase complex; nucleolus; nucleoplasm; nucleus
Molecular Function: acetyltransferase activity; histone acetyltransferase activity; protein binding; transcription coactivator activity
Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA double-strand break processing; DNA replication; DNA synthesis during DNA repair; double-strand break repair; double-strand break repair via nonhomologous end joining; histone acetylation; negative regulation of interleukin-2 production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; response to ionizing radiation; strand displacement
Research Articles on KAT5
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Pathways associated with KAT5 cdna clone
Diseases associated with KAT5 cdna clone
Organs/Tissues associated with KAT5 cdna clone
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