BC001353
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
72,334 Da
NCBI Official Full Name
Homo sapiens katanin p80 (WD repeat containing) subunit B 1, mRNA
NCBI Official Synonym Full Names
katanin regulatory subunit B1
NCBI Official Synonym Symbols
NCBI Protein Information
katanin p80 WD40 repeat-containing subunit B1
UniProt Protein Name
Katanin p80 WD40 repeat-containing subunit B1
UniProt Synonym Protein Names
p80 katanin
UniProt Synonym Gene Names
UniProt Entry Name
KTNB1_HUMAN
NCBI Summary for KATNB1
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]
UniProt Comments for KATNB1
KATNB1: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. Belongs to the WD repeat KATNB1 family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q21
Cellular Component: cytoplasm; katanin complex; membrane; microtubule cytoskeleton; nucleus; plasma membrane; spindle pole
Molecular Function: microtubule-severing ATPase activity; protein heterodimerization activity
Biological Process: negative regulation of microtubule depolymerization; positive regulation of microtubule depolymerization
Disease: Lissencephaly 6, With Microcephaly
Research Articles on KATNB1
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Diseases associated with KATNB1 cdna clone
Organs/Tissues associated with KATNB1 cdna clone
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