BC006534
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,866 Da
NCBI Official Full Name
Homo sapiens kelch repeat and BTB (POZ) domain containing 10, mRNA
NCBI Official Synonym Full Names
kelch like family member 41
NCBI Protein Information
kelch-like protein 41
UniProt Protein Name
Kelch-like protein 41
UniProt Synonym Protein Names
Kel-like protein 23; Kelch repeat and BTB domain-containing protein 10; Kelch-related protein 1; Sarcosin
UniProt Synonym Gene Names
UniProt Entry Name
KLH41_HUMAN
NCBI Summary for KBTBD10
This gene is a member of the kelch-like family. The encoded protein contains a BACK domain, a BTB/POZ domain, and 5 Kelch repeats. This protein is thought to function in skeletal muscle development and maintenance. Mutations in this gene have been associated with nemaline myopathy (NM), a rare congenital muscle disorder. [provided by RefSeq, Mar 2015]
UniProt Comments for KBTBD10
KBTBD10: Required for pseudopod elongation in transformed cells. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; Cell adhesion; Contractile; Cytoskeletal
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component: cytoplasm; cytoskeleton; endoplasmic reticulum membrane; M band; nucleus; plasma membrane; sarcoplasmic reticulum membrane
Molecular Function: protein binding; ubiquitin-protein ligase activity
Biological Process: myofibril assembly; protein ubiquitination; regulation of myoblast differentiation; sarcomere organization; skeletal muscle fiber development; striated muscle contraction
Disease: Nemaline Myopathy 9
Research Articles on KBTBD10
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Diseases associated with KBTBD10 cdna clone
Organs/Tissues associated with KBTBD10 cdna clone
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