BC035059
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63,842 Da
NCBI Official Full Name
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 3, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily A member 3
NCBI Official Synonym Symbols
MK3; HGK5; HLK3; PCN3; HPCN3; KV1.3; HUKIII [Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily A member 3
UniProt Protein Name
Potassium voltage-gated channel subfamily A member 3
UniProt Synonym Protein Names
HGK5; HLK3; HPCN3; Voltage-gated K(+) channel HuKIII; Voltage-gated potassium channel subunit Kv1.3
UniProt Synonym Gene Names
UniProt Entry Name
KCNA3_HUMAN
NCBI Summary for KCNA3
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNA3
Kv1.3: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, potassium
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: plasma membrane
Molecular Function: delayed rectifier potassium channel activity; voltage-gated ion channel activity
Biological Process: potassium ion transport
Research Articles on KCNA3
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Pathways associated with KCNA3 cdna clone
Diseases associated with KCNA3 cdna clone
Organs/Tissues associated with KCNA3 cdna clone
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