BC099665
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,427 Da
NCBI Official Full Name
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 5, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily A member 5
NCBI Official Synonym Symbols
HK2; HCK1; PCN1; ATFB7; HPCN1; KV1.5 [Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily A member 5
UniProt Protein Name
Potassium voltage-gated channel subfamily A member 5
UniProt Synonym Protein Names
HPCN1; Voltage-gated potassium channel HK2; Voltage-gated potassium channel subunit Kv1.5
UniProt Entry Name
KCNA5_HUMAN
NCBI Summary for KCNA5
Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]
UniProt Comments for KCNA5
Kv1.5: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation. Defects in KCNA5 are the cause of familial atrial fibrillation type 7 (ATFB7). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: caveola; Golgi apparatus; integral to plasma membrane; lipid raft; plasma membrane; voltage-gated potassium channel complex
Molecular Function: alpha-actinin binding; delayed rectifier potassium channel activity; outward rectifier potassium channel activity; protein binding; protein kinase binding
Biological Process: membrane hyperpolarization; potassium ion transport; regulation of insulin secretion; regulation of membrane potential; regulation of potassium ion transport
Disease: Atrial Fibrillation, Familial, 7
Research Articles on KCNA5
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Pathways associated with KCNA5 cdna clone
Diseases associated with KCNA5 cdna clone
Organs/Tissues associated with KCNA5 cdna clone
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