BC069355
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UniProt Related Accession #
Molecular Weight
58,729 Da
NCBI Official Full Name
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 6, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily A member 6
NCBI Protein Information
potassium voltage-gated channel subfamily A member 6
UniProt Protein Name
Potassium voltage-gated channel subfamily A member 6
UniProt Synonym Protein Names
Voltage-gated potassium channel HBK2
UniProt Entry Name
KCNA6_HUMAN
NCBI Summary for KCNA6
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNA6
Kv1.6: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: integral to plasma membrane; plasma membrane; voltage-gated potassium channel complex
Molecular Function: delayed rectifier potassium channel activity; voltage-gated potassium channel activity
Biological Process: potassium ion transport
Research Articles on KCNA6
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Pathways associated with KCNA6 cdna clone
Diseases associated with KCNA6 cdna clone
Organs/Tissues associated with KCNA6 cdna clone
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