BC043166
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,492 Da
NCBI Official Full Name
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, beta member 1, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
NCBI Official Synonym Symbols
hKvb3; AKR6A3; KCNA1B; Kvb1.3; hKvBeta3; KV-BETA-1 [Similar Products]
NCBI Protein Information
voltage-gated potassium channel subunit beta-1
UniProt Protein Name
Voltage-gated potassium channel subunit beta-1
UniProt Synonym Protein Names
K(+) channel subunit beta-1; Kv-beta-1
UniProt Synonym Gene Names
UniProt Entry Name
KCAB1_HUMAN
NCBI Summary for KCNAB1
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Apr 2015]
UniProt Comments for KCNAB1
Kv-beta1: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1. Belongs to the shaker potassium channel beta subunit family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, potassium
Chromosomal Location of Human Ortholog: 3q26.1
Cellular Component: cytosol; extrinsic to internal side of plasma membrane; plasma membrane
Molecular Function: aldo-keto reductase activity; potassium channel regulator activity
Biological Process: potassium ion transport
Research Articles on KCNAB1
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Pathways associated with KCNAB1 cdna clone
Diseases associated with KCNAB1 cdna clone
Organs/Tissues associated with KCNAB1 cdna clone
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