BC126424
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,560 Da
NCBI Official Full Name
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, beta member 2, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily A regulatory beta subunit 2
NCBI Official Synonym Symbols
AKR6A5; KCNA2B; HKvbeta2; KV-BETA-2; HKvbeta2.1; HKvbeta2.2 [Similar Products]
NCBI Protein Information
voltage-gated potassium channel subunit beta-2
UniProt Protein Name
Voltage-gated potassium channel subunit beta-2
UniProt Synonym Protein Names
K(+) channel subunit beta-2; Kv-beta-2; hKvbeta2
UniProt Synonym Gene Names
UniProt Entry Name
KCAB2_HUMAN
NCBI Summary for KCNAB2
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]
UniProt Comments for KCNAB2
Kv-beta2: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters functional properties of Kv1.4. Forms heteromultimeric complex with alpha subunits. Forms a ternary complex with SQSTM1 and PRKCZ. Belongs to the shaker potassium channel beta subunit family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, potassium
Chromosomal Location of Human Ortholog: 1p36.3
Cellular Component: cytosol; extrinsic to internal side of plasma membrane; membrane; microtubule; plasma membrane; voltage-gated potassium channel complex
Molecular Function: aldo-keto reductase activity; potassium channel regulator activity
Research Articles on KCNAB2
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Pathways associated with KCNAB2 cdna clone
Diseases associated with KCNAB2 cdna clone
Organs/Tissues associated with KCNAB2 cdna clone
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