BC107129
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,871 Da
NCBI Official Full Name
Homo sapiens potassium voltage-gated channel, Shaw-related subfamily, member 1, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily C member 1
NCBI Protein Information
potassium voltage-gated channel subfamily C member 1
UniProt Protein Name
Potassium voltage-gated channel subfamily C member 1
UniProt Synonym Protein Names
NGK2; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4
UniProt Entry Name
KCNC1_HUMAN
NCBI Summary for KCNC1
This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014]
UniProt Comments for KCNC1
Kv3.1 iso2: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11p15
Cellular Component: plasma membrane; voltage-gated potassium channel complex
Molecular Function: delayed rectifier potassium channel activity; voltage-gated potassium channel activity
Biological Process: potassium ion transport; protein tetramerization
Disease: Epilepsy, Progressive Myoclonic 7
Research Articles on KCNC1
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Pathways associated with KCNC1 cdna clone
Diseases associated with KCNC1 cdna clone
Organs/Tissues associated with KCNC1 cdna clone
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