BC110449
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,537 Da
NCBI Official Full Name
Homo sapiens potassium voltage-gated channel, Shal-related subfamily, member 2, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily D member 2
NCBI Official Synonym Symbols
NCBI Protein Information
potassium voltage-gated channel subfamily D member 2
UniProt Protein Name
Potassium voltage-gated channel subfamily D member 2
UniProt Synonym Protein Names
Voltage-gated potassium channel subunit Kv4.2
UniProt Synonym Gene Names
UniProt Entry Name
KCND2_HUMAN
NCBI Summary for KCND2
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]
UniProt Comments for KCND2
Kv4.2: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7q31
Cellular Component: dendritic spine; integral to plasma membrane; intrinsic to plasma membrane; plasma membrane; postsynaptic membrane; voltage-gated potassium channel complex
Molecular Function: A-type (transient outward) potassium channel activity; delayed rectifier potassium channel activity; protein binding; voltage-gated potassium channel activity
Biological Process: regulation of action potential; synaptic transmission
Research Articles on KCND2
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Pathways associated with KCND2 cdna clone
Diseases associated with KCND2 cdna clone
Organs/Tissues associated with KCND2 cdna clone
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