BC113475
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
71,392 Da
NCBI Official Full Name
Homo sapiens potassium voltage-gated channel, Shal-related subfamily, member 3, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily D member 3
NCBI Official Synonym Symbols
KV4.3; SCA19; SCA22; BRGDA9; KCND3L; KCND3S; KSHIVB [Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily D member 3
UniProt Protein Name
Potassium voltage-gated channel subfamily D member 3
UniProt Synonym Protein Names
Voltage-gated potassium channel subunit Kv4.3
UniProt Entry Name
KCND3_HUMAN
NCBI Summary for KCND3
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for KCND3
Kv4.3: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. KCND3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS). Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: plasma membrane; voltage-gated potassium channel complex
Molecular Function: A-type (transient outward) potassium channel activity; delayed rectifier potassium channel activity; protein binding
Biological Process: potassium ion transport
Disease: Brugada Syndrome 9; Spinocerebellar Ataxia 19
Research Articles on KCND3
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Pathways associated with KCND3 cdna clone
Diseases associated with KCND3 cdna clone
Organs/Tissues associated with KCND3 cdna clone
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