BC036452
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,675 Da
NCBI Official Full Name
Homo sapiens potassium voltage-gated channel, Isk-related family, member 1, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily E regulatory subunit 1
NCBI Official Synonym Symbols
ISK; JLNS; LQT5; MinK; JLNS2; LQT2/5 [Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily E member 1
UniProt Protein Name
Potassium voltage-gated channel subfamily E member 1
UniProt Synonym Protein Names
Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Minimal potassium channel
UniProt Entry Name
KCNE1_HUMAN
NCBI Summary for KCNE1
The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNE1
KCNE1: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Associates with KCNQ1/KVLQT1 and KCNH2/HERG. Expressed in heart, lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells. Belongs to the potassium channel KCNE family.
Protein type: Membrane protein, integral; Channel, potassium
Chromosomal Location of Human Ortholog: 21q22.12
Cellular Component: apical plasma membrane; cell surface; lysosome; plasma membrane; voltage-gated potassium channel complex; Z disc
Molecular Function: delayed rectifier potassium channel activity; potassium channel regulator activity; protein binding; telethonin binding; voltage-gated potassium channel activity
Biological Process: protein amino acid N-linked glycosylation; protein amino acid O-linked glycosylation; sensory perception of sound
Disease: Jervell And Lange-nielsen Syndrome 2; Long Qt Syndrome 5
Research Articles on KCNE1
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Diseases associated with KCNE1 cdna clone
Organs/Tissues associated with KCNE1 cdna clone
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