BC014429
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,806 Da
NCBI Official Full Name
Homo sapiens potassium voltage-gated channel, Isk-related family, member 4, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily E regulatory subunit 4
NCBI Official Synonym Symbols
NCBI Protein Information
potassium voltage-gated channel subfamily E member 4
UniProt Protein Name
Potassium voltage-gated channel subfamily E member 4
UniProt Synonym Protein Names
MinK-related peptide 3; Minimum potassium ion channel-related peptide 3; Potassium channel subunit beta MiRP3
UniProt Entry Name
KCNE4_HUMAN
NCBI Summary for KCNE4
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNE4
KCNE4: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current. Belongs to the potassium channel KCNE family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q36.1
Molecular Function: protein binding
Research Articles on KCNE4
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Organs/Tissues associated with KCNE4 cdna clone
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