BC006334
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,298 Da
NCBI Official Full Name
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 6, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily H member 6
NCBI Official Synonym Symbols
ERG2; ERG-2; HERG2; Kv11.2; hERG-2 [Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily H member 6
UniProt Protein Name
Potassium voltage-gated channel subfamily H member 6
UniProt Synonym Protein Names
Ether-a-go-go-related gene potassium channel 2; ERG-2; Eag-related protein 2; Ether-a-go-go-related protein 2; hERG-2; hERG2; Voltage-gated potassium channel subunit Kv11.2
UniProt Synonym Gene Names
ERG2; ERG-2; Eag-related protein 2; Ether-a-go-go-related protein 2; hERG-2; hERG2 [Similar Products]
UniProt Entry Name
KCNH6_HUMAN
NCBI Summary for KCNH6
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
UniProt Comments for KCNH6
Kv11.2: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.2/KCNH6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: voltage-gated potassium channel activity
Biological Process: regulation of membrane potential
Research Articles on KCNH6
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Pathways associated with KCNH6 cdna clone
Diseases associated with KCNH6 cdna clone
Organs/Tissues associated with KCNH6 cdna clone
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