BC012850
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,335 Da
NCBI Official Full Name
Homo sapiens Kv channel interacting protein 3, calsenilin, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel interacting protein 3
NCBI Protein Information
calsenilin
UniProt Protein Name
Calsenilin
UniProt Synonym Protein Names
A-type potassium channel modulatory protein 3; DRE-antagonist modulator; DREAM; Kv channel-interacting protein 3; KChIP3
UniProt Synonym Gene Names
UniProt Entry Name
CSEN_HUMAN
NCBI Summary for KCNIP3
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNIP3
calsenilin: a small calcium-binding protein. Member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Modulates K4 voltage-gated potassium channels. May regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Also functions as a calcium-regulated transcriptional repressor, and to interact with presenilins. May play a role in the regulation of PSEN2 proteolytic processing.
Protein type: Calcium-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q21.1
Cellular Component: cytosol; plasma membrane; voltage-gated potassium channel complex
Molecular Function: DNA binding; potassium channel regulator activity; protein binding; transcription corepressor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; signal transduction
Research Articles on KCNIP3
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Pathways associated with KCNIP3 cdna clone
Diseases associated with KCNIP3 cdna clone
Organs/Tissues associated with KCNIP3 cdna clone
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