BC032520
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,267 Da
NCBI Official Full Name
Homo sapiens Kv channel interacting protein 4, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel interacting protein 4
NCBI Official Synonym Symbols
NCBI Protein Information
Kv channel-interacting protein 4
UniProt Protein Name
Kv channel-interacting protein 4
UniProt Synonym Protein Names
A-type potassium channel modulatory protein 4; Calsenilin-like protein
UniProt Synonym Gene Names
UniProt Entry Name
KCIP4_HUMAN
NCBI Summary for KCNIP4
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNIP4
KCNIP4: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Belongs to the recoverin family. 5 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 4p15.32
Cellular Component: cytoplasm; cytosol; plasma membrane; voltage-gated potassium channel complex
Molecular Function: calcium ion binding; potassium channel regulator activity
Research Articles on KCNIP4
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Pathways associated with KCNIP4 cdna clone
Diseases associated with KCNIP4 cdna clone
Organs/Tissues associated with KCNIP4 cdna clone
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