BC034036
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,508 Da
NCBI Official Full Name
Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 10, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily J member 10
NCBI Official Synonym Symbols
KIR1.2; KIR4.1; SESAME; BIRK-10; KCNJ13-PEN [Similar Products]
NCBI Protein Information
ATP-sensitive inward rectifier potassium channel 10
UniProt Protein Name
ATP-sensitive inward rectifier potassium channel 10
UniProt Synonym Protein Names
ATP-dependent inwardly rectifying potassium channel Kir4.1; Inward rectifier K(+) channel Kir1.2; Potassium channel, inwardly rectifying subfamily J member 10
UniProt Entry Name
KCJ10_HUMAN
NCBI Summary for KCNJ10
This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNJ10
Kir4.1: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Defects in KCNJ10 are the cause of seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SESAMES). A complex disorder characterized by generalized seizures with onset in infancy, delayed psychomotor development, ataxia, sensorineural hearing loss, hypokalemia, metabolic alkalosis, and hypomagnesemia. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.
Protein type: Membrane protein, integral; Channel, potassium; Channel, ligand-gated; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1q23.2
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: ATP-activated inward rectifier potassium channel activity; G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; protein binding
Biological Process: potassium ion import; potassium ion transport
Disease: Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct; Pendred Syndrome; Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance
Research Articles on KCNJ10
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Pathways associated with KCNJ10 cdna clone
Diseases associated with KCNJ10 cdna clone
Organs/Tissues associated with KCNJ10 cdna clone
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