BC027982
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,001 Da
NCBI Official Full Name
Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 12, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily J member 12
NCBI Official Synonym Symbols
IRK2; hIRK; IRK-2; hIRK1; KCNJN1; Kir2.2; Kir2.2v; kcnj12x; hkir2.2x [Similar Products]
NCBI Protein Information
ATP-sensitive inward rectifier potassium channel 12
UniProt Protein Name
ATP-sensitive inward rectifier potassium channel 12
UniProt Synonym Protein Names
Inward rectifier K(+) channel Kir2.2; IRK-2; Inward rectifier K(+) channel Kir2.2v; Potassium channel, inwardly rectifying subfamily J member 12
UniProt Synonym Gene Names
UniProt Entry Name
KCJ12_HUMAN
NCBI Summary for KCNJ12
This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNJ12
KCNJ12: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: integral to plasma membrane; intrinsic to membrane; plasma membrane
Molecular Function: G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity
Biological Process: muscle contraction; potassium ion import; potassium ion transport; protein homotetramerization; regulation of heart contraction
Research Articles on KCNJ12
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Pathways associated with KCNJ12 cdna clone
Diseases associated with KCNJ12 cdna clone
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