BC022495
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,829 Da
NCBI Official Full Name
Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 3, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily J member 3
NCBI Protein Information
G protein-activated inward rectifier potassium channel 1
UniProt Protein Name
G protein-activated inward rectifier potassium channel 1
UniProt Synonym Protein Names
Inward rectifier K(+) channel Kir3.1; Potassium channel, inwardly rectifying subfamily J member 3
UniProt Synonym Gene Names
UniProt Entry Name
KCNJ3_HUMAN
NCBI Summary for KCNJ3
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012]
UniProt Comments for KCNJ3
GIRK1: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q24.1
Cellular Component: plasma membrane; voltage-gated potassium channel complex
Molecular Function: G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; protein binding
Biological Process: potassium ion import; potassium ion transport
Research Articles on KCNJ3
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Pathways associated with KCNJ3 cdna clone
Diseases associated with KCNJ3 cdna clone
Organs/Tissues associated with KCNJ3 cdna clone
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