BC104992
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
98,765 Da
NCBI Official Full Name
Homo sapiens KIAA1033, mRNA
NCBI Official Synonym Full Names
KIAA1033
NCBI Official Synonym Symbols
NCBI Protein Information
WASH complex subunit 7
UniProt Protein Name
WASH complex subunit 7
UniProt Synonym Protein Names
Strumpellin and WASH-interacting protein
UniProt Synonym Gene Names
UniProt Entry Name
WASH7_HUMAN
NCBI Summary for KIAA1033
This gene encodes a component of the WASH complex, which functions in the intracellular transport of endosomes. Mutations in this gene have been detected in individuals with autosomal recessive mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
UniProt Comments for KIAA1033
KIAA1033: Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Belongs to the WASHS7 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: endosome; nucleoplasm
Biological Process: endosome organization and biogenesis; endosome transport
Disease: Mental Retardation, Autosomal Recessive 43
Research Articles on KIAA1033
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Diseases associated with KIAA1033 cdna clone
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