BC017191
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,264 Da
NCBI Official Full Name
Homo sapiens l(3)mbt-like 2 (Drosophila), mRNA
NCBI Official Synonym Full Names
L3MBTL2 polycomb repressive complex 1 subunit
NCBI Protein Information
lethal(3)malignant brain tumor-like protein 2
UniProt Protein Name
Lethal(3)malignant brain tumor-like protein 2
UniProt Synonym Gene Names
UniProt Entry Name
LMBL2_HUMAN
UniProt Comments for L3MBTL2
L3MBTL2: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Histone-binding
Chromosomal Location of Human Ortholog: 22q13.31-q13.33
Cellular Component: nucleoplasm; nucleus
Molecular Function: histone binding; methylated histone residue binding; protein binding
Biological Process: protein sumoylation
Research Articles on L3MBTL2
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Diseases associated with L3MBTL2 cdna clone
Organs/Tissues associated with L3MBTL2 cdna clone
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