BC018445
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,845 Da
NCBI Official Full Name
Homo sapiens lactation elevated 1, mRNA
NCBI Official Synonym Full Names
lactation elevated 1
NCBI Protein Information
lactation elevated protein 1
UniProt Protein Name
Lactation elevated protein 1
UniProt Synonym Protein Names
Protein AFG1 homolog
UniProt Synonym Gene Names
UniProt Entry Name
LACE1_HUMAN
NCBI Summary for LACE1
This gene encodes a mitochondrial integral membrane protein that plays a role in mitochondrial protein homeostasis. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. It functions to mediate the degradation of nuclear-encoded complex IV subunits. Two conserved estrogen receptor binding sites are located within 2.5 kb of this gene. Polymorphisms in this gene have been associated with bipolar disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016]
UniProt Comments for LACE1
LACE1: a protein with possible ATPase function. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. Two conserved estrogen receptor binding sites are located within 2.5 kb of this gene. [provided by RefSeq, Jul 2008]
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 6q22.1
Molecular Function: protein binding
Research Articles on LACE1
Precautions
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Disclaimer
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Diseases associated with LACE1 cdna clone
Organs/Tissues associated with LACE1 cdna clone
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