BC001214
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,172 Da
NCBI Official Full Name
Homo sapiens leucine carboxyl methyltransferase 1, mRNA
NCBI Official Synonym Full Names
leucine carboxyl methyltransferase 1
NCBI Protein Information
leucine carboxyl methyltransferase 1
UniProt Protein Name
Leucine carboxyl methyltransferase 1
UniProt Synonym Protein Names
Protein-leucine O-methyltransferase; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
UniProt Synonym Gene Names
UniProt Entry Name
LCMT1_HUMAN
NCBI Summary for LCMT1
LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]
UniProt Comments for LCMT1
LCMT1: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Belongs to the methyltransferase superfamily. LCMT family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid Metabolism - androgen and estrogen; Amino Acid Metabolism - tyrosine; EC 2.1.1.233; Amino Acid Metabolism - histidine; Other Amino Acids Metabolism - selenoamino acid; Methyltransferase
Chromosomal Location of Human Ortholog: 16p12.1
Cellular Component: cytosol
Molecular Function: C-terminal protein carboxyl methyltransferase activity; protein binding; protein-leucine O-methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity
Biological Process: C-terminal protein amino acid methylation; negative regulation of protein complex assembly; protein amino acid methylation; protein modification process; regulation of apoptosis
Research Articles on LCMT1
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Organs/Tissues associated with LCMT1 cdna clone
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