BC006212
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
72,759 Da
NCBI Official Full Name
Homo sapiens leucine zipper, putative tumor suppressor 2, mRNA
NCBI Official Synonym Full Names
leucine zipper tumor suppressor 2
NCBI Official Synonym Symbols
NCBI Protein Information
leucine zipper putative tumor suppressor 2
UniProt Protein Name
Leucine zipper putative tumor suppressor 2
UniProt Synonym Protein Names
Protein LAPSER1
UniProt Synonym Gene Names
UniProt Entry Name
LZTS2_HUMAN
NCBI Summary for LZTS2
The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for LZTS2
LZTS2: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family.
Protein type: Nuclear export
Chromosomal Location of Human Ortholog: 10q24
Cellular Component: vesicle
Molecular Function: protein binding
Research Articles on LZTS2
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Diseases associated with LZTS2 cdna clone
Organs/Tissues associated with LZTS2 cdna clone
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