BC014082
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,771 Da
NCBI Official Full Name
Homo sapiens MAF1 homolog (S. cerevisiae), mRNA
NCBI Official Synonym Full Names
MAF1 homolog, negative regulator of RNA polymerase III
NCBI Protein Information
repressor of RNA polymerase III transcription MAF1 homolog
UniProt Protein Name
Repressor of RNA polymerase III transcription MAF1 homolog
UniProt Entry Name
MAF1_HUMAN
NCBI Summary for MAF1
This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]
UniProt Comments for MAF1
MAF1: Element of the mTORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: centrosome; cytoplasm; intracellular; intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus
Biological Process: negative regulation of transcription from RNA polymerase III promoter
Research Articles on MAF1
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Diseases associated with MAF1 cdna clone
Organs/Tissues associated with MAF1 cdna clone
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