BC000458
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
5,989 Da
NCBI Official Full Name
Homo sapiens mal, T-cell differentiation protein, mRNA
NCBI Official Synonym Full Names
mal, T-cell differentiation protein
NCBI Protein Information
myelin and lymphocyte protein
UniProt Protein Name
Myelin and lymphocyte protein
UniProt Synonym Protein Names
T-lymphocyte maturation-associated protein
UniProt Entry Name
MAL_HUMAN
NCBI Summary for MAL
The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]
UniProt Comments for MAL
MAL: Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function. Belongs to the MAL family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q11.1
Cellular Component: apical plasma membrane; endoplasmic reticulum; endosome; integral to plasma membrane; lipid raft
Molecular Function: channel activity; lipid binding; protein binding; structural constituent of myelin sheath
Biological Process: apical protein localization; cell differentiation; central nervous system development; lipid raft polarization; myelination
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Diseases associated with MAL cdna clone
Organs/Tissues associated with MAL cdna clone
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